Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity - PubMed (original) (raw)
. 1975 Feb;114(2 pt 2):898-905.
- PMID: 1089721
Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity
P Ralph et al. J Immunol. 1975 Feb.
Abstract
A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages. It forms specific rosettes with erythrocytes in the presence of the corresponding anti-serum. The ascites cells mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes. The contribution of contaminating host cells in the cytotoxic reaction was ruled out by growing the tumor in F1 mice and removing the host cells by anti-H2 serum and complement. The tumor cells have receptors for IgG2a and IgG2b immunoglobulins. The availability of a pure population of effector cells in the immune system allows study of the biochemical processes pursuant to lysis of foreign cells.
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