Automated Talairach atlas labels for functional brain mapping - PubMed (original) (raw)

Automated Talairach atlas labels for functional brain mapping

J L Lancaster et al. Hum Brain Mapp. 2000 Jul.

Abstract

in English, French

An automated coordinate-based system to retrieve brain labels from the 1988 Talairach Atlas, called the Talairach Daemon (TD), was previously introduced [Lancaster et al., 1997]. In the present study, the TD system and its 3-D database of labels for the 1988 Talairach atlas were tested for labeling of functional activation foci. TD system labels were compared with author-designated labels of activation coordinates from over 250 published functional brain-mapping studies and with manual atlas-derived labels from an expert group using a subset of these activation coordinates. Automated labeling by the TD system compared well with authors' labels, with a 70% or greater label match averaged over all locations. Author-label matching improved to greater than 90% within a search range of +/-5 mm for most sites. An adaptive grey matter (GM) range-search utility was evaluated using individual activations from the M1 mouth region (30 subjects, 52 sites). It provided an 87% label match to Brodmann area labels (BA 4 & BA 6) within a search range of +/-5 mm. Using the adaptive GM range search, the TD system's overall match with authors' labels (90%) was better than that of the expert group (80%). When used in concert with authors' deeper knowledge of an experiment, the TD system provides consistent and comprehensive labels for brain activation foci. Additional suggested applications of the TD system include interactive labeling, anatomical grouping of activation foci, lesion-deficit analysis, and neuroanatomy education.

An automated coordinate‐based system to retrieve brain labels from the 1988 Talairach Atlas, called the Talairach Daemon (TD), was previously introduced [Lancaster et al., 1997]. In the present study, the TD system and its 3‐D database of labels for the 1988 Talairach atlas were tested for labeling of functional activation foci. TD system labels were compared with author‐designated labels of activation coordinates from over 250 published functional brain‐mapping studies and with manual atlas‐derived labels from an expert group using a subset of these activation coordinates. Automated labeling by the TD system compared well with authors' labels, with a 70% or greater label match averaged over all locations. Author‐label matching improved to greater than 90% within a search range of ±5 mm for most sites. An adaptive grey matter (GM) range‐search utility was evaluated using individual activations from the M1 mouth region (30 subjects, 52 sites). It provided an 87% label match to Brodmann area labels (BA 4 & BA 6) within a search range of ±5 mm. Using the adaptive GM range search, the TD system's overall match with authors' labels (90%) was better than that of the expert group (80%). When used in concert with authors' deeper knowledge of an experiment, the TD system provides consistent and comprehensive labels for brain activation foci. Additional suggested applications of the TD system include interactive labeling, anatomical grouping of activation foci, lesion‐deficit analysis, and neuroanatomy education. Hum. Brain Mapping 10:120–131, 2000. © 2000 Wiley‐Liss, Inc.

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Figures

Figure 1

Figure 1

A typical set of 3‐D data used to create the volume occupancy (VOTL) database around the z = +1 level. Openings in Lobe through Cell levels were provided to emphasize the 3‐D nature of data at each level.

Figure 2

Figure 2

Example of VOTL region labels for a Talairach atlas section image at the z = + 1 level. Lobe labels are illustrated with patterned color fills. Several Brodmann areas (cell level) are illustrated on the top left using solid color fills. Several gyral level structures are illustrated on the bottom left using bold color outlines.

Figure 3

Figure 3

Percent match between TD and ten author‐designated labels as a function of the search range in mm. Data was calculated from 670 points reported by numerous authors. The legend data is ordered by initial percent match (search range = 0 mm). The numbers after each label are organized as follows: (# of different first authors, # of points for the label).

Figure 4

Figure 4

The BrainMap™ Search & View 4.1 application provides direct access to the VOTL (Talairach labels) database to obtain anatomical labels. A coordinate returned following a search on Brodmann area 10 was used to automatically retrieve its hierarchical label.

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