Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations - PubMed (original) (raw)
. 2000 Jun;13(6 Pt 1):704-9.
doi: 10.1016/s0895-7061(00)00238-7.
A C Hsuing, K D Wu, M S Chang, Y T Chen, J Hebert, Y I Chen, R Olshen, D Curb, V Dzau, D Botstein, D Cox, N Risch
Affiliations
- PMID: 10912757
- DOI: 10.1016/s0895-7061(00)00238-7
Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations
K Ranade et al. Am J Hypertens. 2000 Jun.
Abstract
Recent studies have found the tryptophan allele of a glycine to tryptophan polymorphism at position 460 (G460W) of the alpha-adducin protein to be associated with essential hypertension in European populations. We examined whether the tryptophan allele is associated with hypertension in a different population, comprised of subjects of Chinese origin from Taiwan, and Chinese and Japanese origin from the San Francisco Bay area and Hawaii. We adapted the 5' allelic discrimination assay or TaqMan to type individuals for the G460W polymorphism, and using this method we typed more than 1000 individuals. The frequency of the W allele was slightly increased in the treated subjects in the Chinese population (0.458 v 0.423) but not the Japanese population (0.549 v 0.558). We considered dominant, recessive, and additive models in our analysis. There was a significant result for a recessive model for systolic blood pressure in the Chinese population (chi2 6.84, df = 2, P < .05), but only suggestive evidence for diastolic blood pressure (chi2 3.30). In contrast, in the Japanese population, there was no evidence for a positive association under any model. For the combined Chinese and Japanese samples, the evidence for association with alpha-adducin was not significant.
Comment in
- All for one and one for all: introduction to a coordinated analysis of the Gly-460-Trp alpha-adducin polymorphism.
Boerwinkle E; Family Blood Pressure Program. Boerwinkle E, et al. Am J Hypertens. 2000 Jun;13(6 Pt 1):734-5. doi: 10.1016/s0895-7061(00)00243-0. Am J Hypertens. 2000. PMID: 10912761 Review. No abstract available. - Association and linkage analysis of alpha-adducin polymorphism: is the glass half full or half empty?
Bianchi G, Cusi D. Bianchi G, et al. Am J Hypertens. 2000 Jun;13(6 Pt 1):739-43. doi: 10.1016/s0895-7061(00)00241-7. Am J Hypertens. 2000. PMID: 10912763 Review. No abstract available.
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