Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage - PubMed (original) (raw)

. 2000 Aug 2;274(2):467-71.

doi: 10.1006/bbrc.2000.3167.

Affiliations

• PMID: 10913361
• DOI: 10.1006/bbrc.2000.3167

Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage

J Iqbal et al. Biochem Biophys Res Commun. 2000.

Abstract

The synthesis of proteoglycans was measured in normal equine articular cartilage of ages 9 months to 20 years and the effect of TGF-beta1 on this activity was investigated. The rate of incorporation of [(35)S]Na(2)SO(4) decreased with age as did the responsiveness of the tissue to the growth factor. The enhanced synthesis of proteoglycan induced at all ages by TGF-beta1 was down-regulated by IL-1 beta and retinoic acid. The expression of mRNA for TGF-beta1, 2, and 3 was also measured, and although the level of TGF-beta1 was highest at all ages, the expression of each growth factor decreased with age.

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