Nonsense-mediated decay mutants do not affect programmed -1 frameshifting - PubMed (original) (raw)
Nonsense-mediated decay mutants do not affect programmed -1 frameshifting
L Bidou et al. RNA. 2000 Jul.
Abstract
Sequences in certain mRNAs program the ribosome to undergo a noncanonical translation event, translational frameshifting, translational hopping, or termination readthrough. These sequences are termed recoding sites, because they cause the ribosome to change temporarily its coding rules. Cis and trans-acting factors sensitively modulate the efficiency of recoding events. In an attempt to quantitate the effect of these factors we have developed a dual-reporter vector using the lacZ and luc genes to directly measure recoding efficiency. We were able to confirm the effect of several factors that modulate frameshift or readthrough efficiency at a variety of sites. Surprisingly, we were not able to confirm that the complex of factors termed the surveillance complex regulates translational frameshifting. This complex regulates degradation of nonsense codon-containing mRNAs and we confirm that it also affects the efficiency of nonsense suppression. Our data suggest that the surveillance complex is not a general regulator of translational accuracy, but that its role is closely tied to the translational termination and initiation processes.
Comment in
- The case for the involvement of the Upf3p in programmed -1 ribosomal frameshifting.
Dinman J, Ruiz-Echevarria M, Wang W, Peltz S. Dinman J, et al. RNA. 2000 Dec;6(12):1685-6. doi: 10.1017/s1355838200001886. RNA. 2000. PMID: 11142366 Free PMC article. No abstract available.
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