Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis - PubMed (original) (raw)
. 2000 Jul 6;19(29):3256-65.
doi: 10.1038/sj.onc.1203654.
Affiliations
- PMID: 10918582
- DOI: 10.1038/sj.onc.1203654
Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis
T L Timme et al. Oncogene. 2000.
Abstract
Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression. We used the well-characterized Rat1AmycERT cells to show that the caveolin-1 gene is down-regulated at the level of transcription by c-myc. By maintaining relatively high levels of caveolin-1 with an adenoviral vector or in stably transfected clones we show that caveolin-1 can suppress c-myc-induced apoptosis. Further we established human prostate cancer cell lines with the mycER construct and show that clones with increased caveolin-1 are more resistant to myc-induced apoptosis and have increased capacity for growth in soft agar when c-myc is activated.
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