When did the human population size start increasing? - PubMed (original) (raw)
When did the human population size start increasing?
J D Wall et al. Genetics. 2000 Aug.
Abstract
We analyze the frequency spectra of all available human nuclear sequence data sets by using a model of constant population size followed by exponential growth. Parameters of growth (more extreme than or) comparable to what has been suggested from mtDNA data can be rejected for 6 out of the 10 largest data sets. When the data are separated into African and non-African samples, a constant size no-growth model can be rejected for 4 out of 8 non-African samples. Long-term growth (i.e., starting 50-100 kya) can be rejected for 2 out of 8 African samples and 5 out of 8 non-African ones. Under more complex demographic models, including a bottleneck or population subdivision, more of the data are compatible with long-term growth. One problem with the data used here is that a subset of loci may reflect the action of natural selection as well as of demography. It remains possible that the correct demographic model is one of constant population size followed by long-term growth but that at several loci the demographic signature has been obscured by balancing or diversifying selection. However, it is not clear that the data at these loci are consistent with a simple model of balancing selection; more complicated selective alternatives cannot be tested unless they are made explicit. An alternative explanation is that population size growth is more recent (e.g., upper Paleolithic) and that some of the loci have experienced recent directional selection. Given the available data, the latter hypothesis seems more likely.
Similar articles
- Genetic evidence for unequal effective population sizes of human females and males.
Wilder JA, Mobasher Z, Hammer MF. Wilder JA, et al. Mol Biol Evol. 2004 Nov;21(11):2047-57. doi: 10.1093/molbev/msh214. Epub 2004 Aug 18. Mol Biol Evol. 2004. PMID: 15317874 - Contrasting signatures of population growth for mitochondrial DNA and Y chromosomes among human populations in Africa.
Pilkington MM, Wilder JA, Mendez FL, Cox MP, Woerner A, Angui T, Kingan S, Mobasher Z, Batini C, Destro-Bisol G, Soodyall H, Strassmann BI, Hammer MF. Pilkington MM, et al. Mol Biol Evol. 2008 Mar;25(3):517-25. doi: 10.1093/molbev/msm279. Epub 2007 Dec 18. Mol Biol Evol. 2008. PMID: 18093995 - mtDNA variation predicts population size in humans and reveals a major Southern Asian chapter in human prehistory.
Atkinson QD, Gray RD, Drummond AJ. Atkinson QD, et al. Mol Biol Evol. 2008 Feb;25(2):468-74. doi: 10.1093/molbev/msm277. Epub 2007 Dec 18. Mol Biol Evol. 2008. PMID: 18093996 - Human demographic history: refining the recent African origin model.
Excoffier L. Excoffier L. Curr Opin Genet Dev. 2002 Dec;12(6):675-82. doi: 10.1016/s0959-437x(02)00350-7. Curr Opin Genet Dev. 2002. PMID: 12433581 Review. - Selective Sweeps.
Stephan W. Stephan W. Genetics. 2019 Jan;211(1):5-13. doi: 10.1534/genetics.118.301319. Genetics. 2019. PMID: 30626638 Free PMC article. Review.
Cited by
- Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.
Campbell MC, Ashong B, Teng S, Harvey J, Cross CN. Campbell MC, et al. BMC Evol Biol. 2019 Dec 2;19(1):218. doi: 10.1186/s12862-019-1516-y. BMC Evol Biol. 2019. PMID: 31791241 Free PMC article. - Conservation Genomics of the Declining North American Bumblebee Bombus terricola Reveals Inbreeding and Selection on Immune Genes.
Kent CF, Dey A, Patel H, Tsvetkov N, Tiwari T, MacPhail VJ, Gobeil Y, Harpur BA, Gurtowski J, Schatz MC, Colla SR, Zayed A. Kent CF, et al. Front Genet. 2018 Aug 10;9:316. doi: 10.3389/fgene.2018.00316. eCollection 2018. Front Genet. 2018. PMID: 30147708 Free PMC article. - A population genetic interpretation of GWAS findings for human quantitative traits.
Simons YB, Bullaughey K, Hudson RR, Sella G. Simons YB, et al. PLoS Biol. 2018 Mar 16;16(3):e2002985. doi: 10.1371/journal.pbio.2002985. eCollection 2018 Mar. PLoS Biol. 2018. PMID: 29547617 Free PMC article. - The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.
Simons YB, Sella G. Simons YB, et al. Curr Opin Genet Dev. 2016 Dec;41:150-158. doi: 10.1016/j.gde.2016.09.006. Epub 2016 Oct 13. Curr Opin Genet Dev. 2016. PMID: 27744216 Free PMC article. Review. - Explosive genetic evidence for explosive human population growth.
Gao F, Keinan A. Gao F, et al. Curr Opin Genet Dev. 2016 Dec;41:130-139. doi: 10.1016/j.gde.2016.09.002. Epub 2016 Oct 4. Curr Opin Genet Dev. 2016. PMID: 27710906 Free PMC article. Review.
References
- Genetics. 1989 Nov;123(3):585-95 - PubMed
- Science. 1988 Mar 11;239(4845):1263-8 - PubMed
- Trends Ecol Evol. 1999 Jan;14(1):35-38 - PubMed
- Genet Res. 1974 Feb;23(1):23-35 - PubMed
- Genetics. 1993 Mar;133(3):693-709 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources