Interactions between insulin resistance and insulin secretion in the development of glucose intolerance - PubMed (original) (raw)
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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
M K Cavaghan et al. J Clin Invest. 2000 Aug.
No abstract available
Figures
Figure 1
Plasma insulin concentrations (a) and insulin secretion rates (b) in response to molar increments in the plasma glucose concentration during a graded glucose infusion in insulin-resistant (dashed line) and insulin-sensitive (solid line) groups. Reprinted with permission (4).
Figure 2
Dose-response relationships between glucose and insulin secretory rate (ISR) after overnight fast in control subjects (CON; filled circles), normoglycemic subjects with family history of non–insulin-dependent diabetes mellitus (FDR, first-degree relative; open squares), subjects with nondiagnostic oral glucose tolerance test (NDX; filled triangles), subjects with impaired glucose tolerance (IGT; open diamonds), and subjects with non–insulin-dependent diabetes mellitus (NIDDM; open triangles). BMI, body mass index. Reprinted with permission (21).
References
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- Coleman DL, Hummel KP. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia. 1973;9:287–293. - PubMed
- Jones CNO, et al. Alterations in the glucose-stimulated insulin secretory dose-reponse curve and in insulin clearance in nondiabetic insulin-resistant individuals. J Clin Endocrinol Metab. 1997;82:1834–1838. - PubMed
- Kahn SE, et al. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes. 1993;42:1663–1672. - PubMed
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