Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology - PubMed (original) (raw)

Review

doi: 10.1038/78592.

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• PMID: 10932210
• DOI: 10.1038/78592

Review

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

W E Wright et al. Nat Med. 2000 Aug.

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

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