Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies - PubMed (original) (raw)
Review
Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies
M D'Esposito et al. Exp Brain Res. 2000 Jul.
Abstract
Working memory refers to the short-term retention of information that is no longer accessible in the environment, and the manipulation of this information, for subsequent use in guiding behavior. In this review, we will present data from a series of event-related functional magnetic-resonance-imaging (fMRI) studies of delayed-response tasks that were designed to investigate the role of different regions of the prefrontal cortex (PFC) during different working-memory component processes. From these data, we conclude that: (1) lateral PFC is anatomically organized according to the types of cognitive operations that one performs when attempting to temporarily maintain and manipulate information; and (2) consistent with the picture that has emerged from the monkey electrophysiological literature, human lateral PFC is involved in several encoding- and response-related processes as well as mnemonic and nonmnemonic processes that are engaged during the temporary maintenance of information. Thus, lateral PFC activity cannot be ascribed to the function of a single, unitary cognitive operation.
Similar articles
- Maintaining structured information: an investigation into functions of parietal and lateral prefrontal cortices.
Wendelken C, Bunge SA, Carter CS. Wendelken C, et al. Neuropsychologia. 2008 Jan 31;46(2):665-78. doi: 10.1016/j.neuropsychologia.2007.09.015. Epub 2007 Oct 6. Neuropsychologia. 2008. PMID: 18022652 - Dissecting contributions of prefrontal cortex and fusiform face area to face working memory.
Druzgal TJ, D'Esposito M. Druzgal TJ, et al. J Cogn Neurosci. 2003 Aug 15;15(6):771-84. doi: 10.1162/089892903322370708. J Cogn Neurosci. 2003. PMID: 14511531 - Human prefrontal cortex is not specific for working memory: a functional MRI study.
D'Esposito M, Ballard D, Aguirre GK, Zarahn E. D'Esposito M, et al. Neuroimage. 1998 Oct;8(3):274-82. doi: 10.1006/nimg.1998.0364. Neuroimage. 1998. PMID: 9758741 - From cognitive to neural models of working memory.
D'Esposito M. D'Esposito M. Philos Trans R Soc Lond B Biol Sci. 2007 May 29;362(1481):761-72. doi: 10.1098/rstb.2007.2086. Philos Trans R Soc Lond B Biol Sci. 2007. PMID: 17400538 Free PMC article. Review. - Segregation of working memory functions within the dorsolateral prefrontal cortex.
Levy R, Goldman-Rakic PS. Levy R, et al. Exp Brain Res. 2000 Jul;133(1):23-32. doi: 10.1007/s002210000397. Exp Brain Res. 2000. PMID: 10933207 Review.
Cited by
- Executive working memory load induces inattentional blindness.
Fougnie D, Marois R. Fougnie D, et al. Psychon Bull Rev. 2007 Feb;14(1):142-7. doi: 10.3758/bf03194041. Psychon Bull Rev. 2007. PMID: 17546744 - Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats.
Petschner P, Tamasi V, Adori C, Kirilly E, Ando RD, Tothfalusi L, Bagdy G. Petschner P, et al. BMC Genomics. 2018 Aug 2;19(1):580. doi: 10.1186/s12864-018-4929-x. BMC Genomics. 2018. PMID: 30071829 Free PMC article. - Neurocognitive Operations Underlying Working Memory Abilities: An Analysis of Latency and Time-Based Parameters.
Emrani S, Lamar M, Price CC, Swenson R, Libon DJ, Baliga G. Emrani S, et al. J Alzheimers Dis. 2023;94(4):1535-1547. doi: 10.3233/JAD-230288. J Alzheimers Dis. 2023. PMID: 37458036 Free PMC article. - fMRI-activation patterns in the detection of concealed information rely on memory-related effects.
Gamer M, Klimecki O, Bauermann T, Stoeter P, Vossel G. Gamer M, et al. Soc Cogn Affect Neurosci. 2012 Jun;7(5):506-15. doi: 10.1093/scan/nsp005. Epub 2009 Mar 3. Soc Cogn Affect Neurosci. 2012. PMID: 19258375 Free PMC article. - The neural basis of involuntary episodic memories.
Hall SA, Rubin DC, Miles A, Davis SW, Wing EA, Cabeza R, Berntsen D. Hall SA, et al. J Cogn Neurosci. 2014 Oct;26(10):2385-99. doi: 10.1162/jocn_a_00633. Epub 2014 Apr 4. J Cogn Neurosci. 2014. PMID: 24702453 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous