The current use of botulinum toxin - PubMed (original) (raw)

Review

The current use of botulinum toxin

N Mahant et al. J Clin Neurosci. 2000 Sep.

Abstract

Botulinum toxin is the most potent neurotoxin known, and has been in clinical use since the late 1970s. The toxin inhibits the release of acetylcholine from nerve terminals by inhibiting transport of the synaptic vesicles, thus causing functional denervation lasting up to 6 months. Our understanding of the mechanism of action of the toxin and the spectrum of diseases treatable with this agent continues to increase. Efficacy has been demonstrated in hemifacial spasm, dystonia, spasticity, hyperhidrosis and other conditions. Alternative serotypes are used in some centres, generally after the development of immunoresistance to the standard toxin (serotype A), and are likely to be in routine use in the near future. This paper reviews the history, pharmacology and current uses of botulinum toxin.

Copyright 2000 Harcourt Publishers Ltd.

PubMed Disclaimer

Similar articles

• [Spasticity and botulinum toxin in 2003. An update].
  Fève A. Fève A. Neurochirurgie. 2003 May;49(2-3 Pt 2):265-70. Neurochirurgie. 2003. PMID: 12746701 Review. French.
• Chemodenervation with botulinum toxin for spasticity and dystonia. The effects on gait.
  O'Brien CF. O'Brien CF. Adv Neurol. 2001;87:265-9. Adv Neurol. 2001. PMID: 11347231 Review. No abstract available.
• Botulinum toxins: pharmacology and its current therapeutic evidence for use.
  Panicker JN, Muthane UB. Panicker JN, et al. Neurol India. 2003 Dec;51(4):455-60. Neurol India. 2003. PMID: 14742921 Review.
• Botulinum toxin in movement disorders.
  Papapetropoulos S, Singer C. Papapetropoulos S, et al. Semin Neurol. 2007 Apr;27(2):183-94. doi: 10.1055/s-2007-971171. Semin Neurol. 2007. PMID: 17390263 Review.
• [Botulinum toxins for pain].
  Soinila S, Haanpää M. Soinila S, et al. Duodecim. 2011;127(22):2425-30. Duodecim. 2011. PMID: 22238920 Review. Finnish.

Cited by

• Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells.
  Dong M, Richards DA, Goodnough MC, Tepp WH, Johnson EA, Chapman ER. Dong M, et al. J Cell Biol. 2003 Sep 29;162(7):1293-303. doi: 10.1083/jcb.200305098. Epub 2003 Sep 22. J Cell Biol. 2003. PMID: 14504267 Free PMC article.
• Effective Locations for Injecting Botulinum Toxin into the Mentalis Muscle; Cadaveric and Ultrasonographic Study.
  Choi DY, Bae H, Bae JH, Kim HJ, Hu KS. Choi DY, et al. Toxins (Basel). 2021 Jan 27;13(2):96. doi: 10.3390/toxins13020096. Toxins (Basel). 2021. PMID: 33514053 Free PMC article.
• Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles.
  Seok H, Kim SG. Seok H, et al. Toxins (Basel). 2018 Jan 2;10(1):27. doi: 10.3390/toxins10010027. Toxins (Basel). 2018. PMID: 29301317 Free PMC article. Review.
• Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers.
  Moon YM, Kim MK, Kim SG, Kim TW. Moon YM, et al. Springerplus. 2016 Jul 7;5(1):991. doi: 10.1186/s40064-016-2680-9. eCollection 2016. Springerplus. 2016. PMID: 27398270 Free PMC article.
• Clinical uses of botulinum neurotoxins: current indications, limitations and future developments.
  Chen S. Chen S. Toxins (Basel). 2012 Oct;4(10):913-39. doi: 10.3390/toxins4100913. Epub 2012 Oct 19. Toxins (Basel). 2012. PMID: 23162705 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information