Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 - PubMed (original) (raw)
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
G A McQuibban et al. Science. 2000.
Abstract
Tissue degradation by the matrix metalloproteinase gelatinase A is pivotal to inflammation and metastases. Recognizing the catalytic importance of substrate-binding exosites outside the catalytic domain, we screened for extracellular substrates using the gelatinase A hemopexin domain as bait in the yeast two-hybrid system. Monocyte chemoattractant protein-3 (MCP-3) was identified as a physiological substrate of gelatinase A. Cleaved MCP-3 binds to CC-chemokine receptors-1, -2, and -3, but no longer induces calcium fluxes or promotes chemotaxis, and instead acts as a general chemokine antagonist that dampens inflammation. This suggests that matrix metalloproteinases are both effectors and regulators of the inflammatory response.
Similar articles
- A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation.
Ali S, Robertson H, Wain JH, Isaacs JD, Malik G, Kirby JA. Ali S, et al. J Immunol. 2005 Jul 15;175(2):1257-66. doi: 10.4049/jimmunol.175.2.1257. J Immunol. 2005. PMID: 16002730 - Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.
Proost P, Struyf S, Couvreur M, Lenaerts JP, Conings R, Menten P, Verhaert P, Wuyts A, Van Damme J. Proost P, et al. J Immunol. 1998 Apr 15;160(8):4034-41. J Immunol. 1998. PMID: 9558113 - Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics.
Overall CM, McQuibban GA, Clark-Lewis I. Overall CM, et al. Biol Chem. 2002 Jul-Aug;383(7-8):1059-66. doi: 10.1515/BC.2002.114. Biol Chem. 2002. PMID: 12437088 Review. - Gelatinase B functions as regulator and effector in leukocyte biology.
Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, Masure S, Proost P, Van Damme J. Opdenakker G, et al. J Leukoc Biol. 2001 Jun;69(6):851-9. J Leukoc Biol. 2001. PMID: 11404367 Review.
Cited by
- Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis.
Li RL, Duan HX, Liang Q, Huang YL, Wang LY, Zhang Q, Wu CJ, Liu SQ, Peng W. Li RL, et al. Front Immunol. 2022 Nov 9;13:1046810. doi: 10.3389/fimmu.2022.1046810. eCollection 2022. Front Immunol. 2022. PMID: 36439173 Free PMC article. Review. - Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro.
de Cabo R, Liu L, Ali A, Price N, Zhang J, Wang M, Lakatta E, Irusta PM. de Cabo R, et al. Aging (Albany NY). 2015 Mar;7(3):152-66. doi: 10.18632/aging.100719. Aging (Albany NY). 2015. PMID: 25855056 Free PMC article. - Matrix Metalloproteinases and Glaucoma.
Kim MH, Lim SH. Kim MH, et al. Biomolecules. 2022 Sep 25;12(10):1368. doi: 10.3390/biom12101368. Biomolecules. 2022. PMID: 36291577 Free PMC article. Review. - Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses.
Özcan S, Alessio N, Acar MB, Mert E, Omerli F, Peluso G, Galderisi U. Özcan S, et al. Aging (Albany NY). 2016 Jul;8(7):1316-29. doi: 10.18632/aging.100971. Aging (Albany NY). 2016. PMID: 27288264 Free PMC article. - Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model.
Choi IS, Yu K, Kim J, De Guzman E, Weisenberger DJ, Oghamian S, Kim HJ, Lee KH, Carroll C, Trinh BN, Kim M, Houshdaran S, Laird PW, Jones PA, Warburton D, Liang G, Koh CJ. Choi IS, et al. Urology. 2013 Jul;82(1):253.e9-15. doi: 10.1016/j.urology.2013.04.010. Urology. 2013. PMID: 23806407 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous