Transplantation of cultured human neuronal cells for patients with stroke - PubMed (original) (raw)

Clinical Trial

. 2000 Aug 22;55(4):565-9.

doi: 10.1212/wnl.55.4.565.

L Wechsler, S Goldstein, C Meltzer, K R Thulborn, J Gebel, P Jannetta, S DeCesare, E M Elder, M McGrogan, M A Reitman, L Bynum

Affiliations

• PMID: 10953194
• DOI: 10.1212/wnl.55.4.565

Clinical Trial

Transplantation of cultured human neuronal cells for patients with stroke

D Kondziolka et al. Neurology. 2000.

Abstract

Transplantation of cultured neuronal cells is safe in animal models and improves motor and cognitive deficits in rats with stroke. The authors studied the safety and feasibility of human neuronal cellular transplantation in patients with basal ganglia stroke and fixed motor deficits, including 12 patients (aged 44 to 75 years) with an infarct 6 months to 6 years previously (stable for at least 2 months). Serial evaluations (12 to 18 months) showed no adverse cell-related serologic or imaging-defined effects. The total European Stroke Scale score improved in six patients (3 to 10 points), with a mean improvement 2.9 points in all patients (p = 0. 046). Six of 11 PET scans at 6 months showed improved fluorodeoxyglucose uptake at the implant site. Neuronal transplantation is feasible in patients with motor infarction.

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Comment in

• Cell transplant therapy for stroke: hope or hype.
  Zivin JA. Zivin JA. Neurology. 2000 Aug 22;55(4):467. doi: 10.1212/wnl.55.4.467. Neurology. 2000. PMID: 10953175 No abstract available.
• Transplantation of cultured human neuronal cells for patients with stroke.
  Buchan AM, Warren D, Burnstein R. Buchan AM, et al. Neurology. 2001 Mar 27;56(6):821-2. doi: 10.1212/wnl.56.6.820-a. Neurology. 2001. PMID: 11274333 No abstract available.

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