Tetrameric coiled coil domain of Sendai virus phosphoprotein - PubMed (original) (raw)

Tetrameric coiled coil domain of Sendai virus phosphoprotein

N Tarbouriech et al. Nat Struct Biol. 2000 Sep.

Abstract

The high resolution X-ray structure of the Sendai virus oligomerization domain reveals a homotetrameric coiled coil structure with many details that are different from classic coiled coils with canonical hydrophobic heptad repeats. Alternatives to the classic knobs-into-holes packing lead to differences in supercoil pitch and diameter that allow water molecules inside the core. This open and more hydrophilic structure does not seem to be destabilized by mutations that would be expected to disrupt classic coiled coils.

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