Dendritic cell regulation of TH1-TH2 development - PubMed (original) (raw)

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doi: 10.1038/79734.

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• PMID: 10973276
• DOI: 10.1038/79734

Review

Dendritic cell regulation of TH1-TH2 development

M Moser et al. Nat Immunol. 2000 Sep.

Abstract

Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription factors. Less is understood about the molecular basis of TH1-TH2 development exerted by other parameters, such as how the antigen presenting cell can influence this process. Recent work suggests that dendritic cell subsets contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. In some cases known pathways may be used, as in the dendritic cell subset 1 exerting TH1 polarization by interleukin 12 (IL-12) production and STAT4 activation. In others, the effects are still in need of explanation.

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