BCL-6 regulates chemokine gene transcription in macrophages - PubMed (original) (raw)
BCL-6 regulates chemokine gene transcription in macrophages
L M Toney et al. Nat Immunol. 2000 Sep.
Abstract
The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.
Comment in
- TH2 inflammation repressed by chemokines.
Canfield S, Rothman P. Canfield S, et al. Nat Immunol. 2000 Sep;1(3):189-90. doi: 10.1038/79720. Nat Immunol. 2000. PMID: 10973271 No abstract available.
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