The L6 membrane proteins--a new four-transmembrane superfamily - PubMed (original) (raw)

Comparative Study

The L6 membrane proteins--a new four-transmembrane superfamily

M D Wright et al. Protein Sci. 2000 Aug.

Abstract

L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.

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