Astrocyte glutamate transport: review of properties, regulation, and physiological functions - PubMed (original) (raw)
Affiliations
- PMID: 10975906
Review
Astrocyte glutamate transport: review of properties, regulation, and physiological functions
C M Anderson et al. Glia. 2000 Oct.
Abstract
Rapid removal of glutamate from the extracellular space is required for the survival and normal function of neurons. Although glutamate transporters are expressed by all CNS cell types, astrocytes are the cell type primarily responsible for glutamate uptake. Astrocyte glutamate uptake also plays a role in regulating the activity of glutamatergic synapses. Lastly, release of glutamate from astrocytes, via transporter reversal and other routes, can contribute to glutamate receptor activation. This review examines the mechanisms of astrocyte glutamate uptake and release, with particular focus on high-affinity Na(+)-dependent transporters. Transporter regulation, energetics, and physiological roles are discussed.
Similar articles
- Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal.
Anderson CM, Bridges RJ, Chamberlin AR, Shimamoto K, Yasuda-Kamatani Y, Swanson RA. Anderson CM, et al. J Neurochem. 2001 Dec;79(6):1207-16. doi: 10.1046/j.1471-4159.2001.00668.x. J Neurochem. 2001. PMID: 11752061 - Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus.
Bergles DE, Jahr CE. Bergles DE, et al. J Neurosci. 1998 Oct 1;18(19):7709-16. doi: 10.1523/JNEUROSCI.18-19-07709.1998. J Neurosci. 1998. PMID: 9742141 Free PMC article. - Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation.
Diamond JS, Jahr CE. Diamond JS, et al. J Neurophysiol. 2000 May;83(5):2835-43. doi: 10.1152/jn.2000.83.5.2835. J Neurophysiol. 2000. PMID: 10805681 - Glutamate uptake.
Danbolt NC. Danbolt NC. Prog Neurobiol. 2001 Sep;65(1):1-105. doi: 10.1016/s0301-0082(00)00067-8. Prog Neurobiol. 2001. PMID: 11369436 Review. - Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription Factors.
Martinez-Lozada Z, Guillem AM, Robinson MB. Martinez-Lozada Z, et al. Adv Pharmacol. 2016;76:103-45. doi: 10.1016/bs.apha.2016.01.004. Epub 2016 Mar 24. Adv Pharmacol. 2016. PMID: 27288076 Free PMC article. Review.
Cited by
- Astrocyte-Mediated Neuroinflammation in Neurological Conditions.
Zhao Y, Huang Y, Cao Y, Yang J. Zhao Y, et al. Biomolecules. 2024 Sep 25;14(10):1204. doi: 10.3390/biom14101204. Biomolecules. 2024. PMID: 39456137 Free PMC article. Review. - PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.
Perrin F, Anderson LC, Mitchell SPC, Sinha P, Turchyna Y, Maesako M, Houser MCQ, Zhang C, Wagner SL, Tanzi RE, Berezovska O. Perrin F, et al. Acta Neuropathol Commun. 2024 Oct 21;12(1):166. doi: 10.1186/s40478-024-01876-y. Acta Neuropathol Commun. 2024. PMID: 39434170 Free PMC article. - The Aging Immune System: A Critical Attack on Ischemic Stroke.
Xu W, Guo Y, Zhao L, Fu R, Qin X, Zhang Y, Cheng X, Xu S. Xu W, et al. Mol Neurobiol. 2024 Sep 14. doi: 10.1007/s12035-024-04464-2. Online ahead of print. Mol Neurobiol. 2024. PMID: 39271626 Review. - Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain.
Abdelaziz MA, Chen WH, Chang YW, Mindaye SA, Chen CC. Abdelaziz MA, et al. PNAS Nexus. 2024 Aug 30;3(9):pgae362. doi: 10.1093/pnasnexus/pgae362. eCollection 2024 Sep. PNAS Nexus. 2024. PMID: 39228816 Free PMC article. - Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes.
Amato S, Averna M, Farsetti E, Guidolin D, Pedrazzi M, Gatta E, Candiani S, Maura G, Agnati LF, Cervetto C, Marcoli M. Amato S, et al. Int J Mol Sci. 2024 Aug 7;25(16):8610. doi: 10.3390/ijms25168610. Int J Mol Sci. 2024. PMID: 39201299 Free PMC article.