ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages - PubMed (original) (raw)
ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
T Tamura et al. Immunity. 2000 Aug.
Free article
Abstract
During hematopoiesis, myeloid progenitor cells give rise to granulocytes and macrophages. To study the role for ICSBP, a hematopoietic cell-specific transcription factor in myeloid cell development, the gene was introduced into myeloid progenitor cells established from ICSBP-/- mice. ICSBP retrovirus-transduced cells differentiated into mature macrophages with phagocytic activity, which coincided with the induction of specific target DNA binding activity. Similar to macrophages in vivo, ICSBP-transduced cells were growth arrested, expressed many macrophage-specific genes, and responded to macrophage activation signals. Contrary to this, ICSBP transducion led to repression of granulocyte-specific genes and inhibited G-CSF-mediated granulocytic differentiation in these and other myeloid progenitor cells. Together, ICSBP has a key role in the myeloid cell lineage selection and macrophage maturation.
Similar articles
- IFN consensus sequence binding protein/IFN regulatory factor-8 guides bone marrow progenitor cells toward the macrophage lineage.
Tsujimura H, Nagamura-Inoue T, Tamura T, Ozato K. Tsujimura H, et al. J Immunol. 2002 Aug 1;169(3):1261-9. doi: 10.4049/jimmunol.169.3.1261. J Immunol. 2002. PMID: 12133947 - Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.
Scheller M, Foerster J, Heyworth CM, Waring JF, Löhler J, Gilmore GL, Shadduck RK, Dexter TM, Horak I. Scheller M, et al. Blood. 1999 Dec 1;94(11):3764-71. Blood. 1999. PMID: 10572090 - ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells.
Tamura T, Kong HJ, Tunyaplin C, Tsujimura H, Calame K, Ozato K. Tamura T, et al. Blood. 2003 Dec 15;102(13):4547-54. doi: 10.1182/blood-2003-01-0291. Epub 2003 Aug 21. Blood. 2003. PMID: 12933588 - ICSBP/IRF-8: its regulatory roles in the development of myeloid cells.
Tamura T, Ozato K. Tamura T, et al. J Interferon Cytokine Res. 2002 Jan;22(1):145-52. doi: 10.1089/107999002753452755. J Interferon Cytokine Res. 2002. PMID: 11846985 Review. - Transcription factors that regulate growth and differentiation of myeloid cells.
Nagamura-Inoue T, Tamura T, Ozato K. Nagamura-Inoue T, et al. Int Rev Immunol. 2001 Feb;20(1):83-105. doi: 10.3109/08830180109056724. Int Rev Immunol. 2001. PMID: 11342299 Review.
Cited by
- The multiple roles of interferon regulatory factor family in health and disease.
Wang L, Zhu Y, Zhang N, Xian Y, Tang Y, Ye J, Reza F, He G, Wen X, Jiang X. Wang L, et al. Signal Transduct Target Ther. 2024 Oct 9;9(1):282. doi: 10.1038/s41392-024-01980-4. Signal Transduct Target Ther. 2024. PMID: 39384770 Free PMC article. Review. - Baf155 controls hematopoietic differentiation and regeneration through chromatin priming.
Wu J, Fan C, Kabir AU, Krchma K, Kim M, Kwon Y, Xing X, Wang T, Choi K. Wu J, et al. Cell Rep. 2024 Aug 27;43(8):114558. doi: 10.1016/j.celrep.2024.114558. Epub 2024 Jul 30. Cell Rep. 2024. PMID: 39088321 Free PMC article. - Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption.
Das A, Yesupatham SK, Allison D, Tanwar H, Gnanasekaran J, Kear B, Wang X, Wang S, Zachariadou C, Abbasi Y, Chung MK, Ozato K, Liu C, Foster BL, Thumbigere-Math V. Das A, et al. J Dent Res. 2024 Mar;103(3):318-328. doi: 10.1177/00220345231222173. Epub 2024 Feb 12. J Dent Res. 2024. PMID: 38343385 - DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8.
Swarnkar G, Semenkovich NP, Arra M, Mims DK, Naqvi SK, Peterson T, Mbalaviele G, Wu CL, Abu-Amer Y. Swarnkar G, et al. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2310264121. doi: 10.1073/pnas.2310264121. Epub 2024 Feb 6. Proc Natl Acad Sci U S A. 2024. PMID: 38319963 Free PMC article. - Immature functional development of lumbar locomotor networks in adult Irf8-/- mice.
Yazawa I, Yoshida Y, Yoshimi R, Ozato K. Yazawa I, et al. Front Neurosci. 2024 Jan 4;17:1234215. doi: 10.3389/fnins.2023.1234215. eCollection 2023. Front Neurosci. 2024. PMID: 38239832 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials