The syntenic relationship of the zebrafish and human genomes - PubMed (original) (raw)
Syntenic relationship between zebrafish linkage group 3 and the human genome. Vertical staff shows map of zebrafish LG3 derived from genes and ESTs (column 1) typed on the LN54 Radiation Hybrid panel 1, or genes and ESTs typed on other panels integrated onto the LN54 map with respect to SSLP markers typed in common. Because gene and EST marker order cannot always be precisely determined when typed on different panels, we show them in high-confidence bins with respect to position of framework markers of the LN54 panel (Hukriede et al. 1999). Order within confidence bins is not established and we have inferred minimal chromosomal rearrangements for our analysis. Superscripts indicate sources of mapping data: (a) the LN54 zebrafish RH panel (Hukriede et al. 1999; this study), (b) the MOP meiotic panel (Johnson et al. 1996;Postlethwait et al. 1998), (c) the GAT meiotic panel (Gates et al. 1999), or (d) the Goodfellow zebrafish RH panel (Geisler et al. 1999). Orthologous human genes (column 2), UniGene reference sequence (
http://www.ncbi.nlm.nih.gov/UniGene
) (column 3), and Gene Map 98 (Deloukas et al. 1998) position (column 4) are shown to right. Conserved synteny groups are as shown as follows: blue, Hsa17; green, Hsa16; light red, Hsa7; dark red, Hsa19; pink, Hsa11; and singletons, black. Contiguous regions with two or more genes from the same conserved synteny group are shaded the corresponding color on the map staff (left). Bold type shows gene (bact2) where determination of orthology was assisted by syntenic relationships. See
, or supplemental information at the Genome Research web site (
) for maps showing other zebrafish-to-human or human-to-zebrafish relationships.