Site-specific retinoic acid production in the brain of adult songbirds - PubMed (original) (raw)
Site-specific retinoic acid production in the brain of adult songbirds
N I Denisenko-Nehrbass et al. Neuron. 2000 Aug.
Free article
Abstract
The song system of songbirds, a set of brain nuclei necessary for song learning and production, has distinctive morphological and functional properties. Utilizing differential display, we searched for molecular components involved in song system regulation. We identified a cDNA (zRalDH) that encodes a class 1 aldehyde dehydrogenase. zRalDH was highly expressed in various song nuclei and synthesized retinoic acid efficiently. Brain areas expressing zRalDH generated retinoic acid. Within song nucleus HVC, only projection neurons not undergoing adult neurogenesis expressed zRalDH. Blocking zRalDH activity in the HVC of juveniles interfered with normal song development. Our results provide conclusive evidence for localized retinoic acid synthesis in an adult vertebrate brain and indicate that the retinoic acid-generating system plays a significant role in the maturation of a learned behavior.
Similar articles
- Organization and development of zebra finch HVC and paraHVC based on expression of zRalDH, an enzyme associated with retinoic acid production.
Olson CR, Rodrigues PV, Jeong JK, Prahl DJ, Mello CV. Olson CR, et al. J Comp Neurol. 2011 Jan 1;519(1):148-61. doi: 10.1002/cne.22510. J Comp Neurol. 2011. PMID: 21120932 Free PMC article. - Molecular targets of disulfiram action on song maturation in zebra finches.
Denisenko-Nehrbass NI, Mello CV. Denisenko-Nehrbass NI, et al. Brain Res Mol Brain Res. 2001 Mar 5;87(2):246-50. doi: 10.1016/s0169-328x(01)00002-x. Brain Res Mol Brain Res. 2001. PMID: 11245927 - Long-distance retinoid signaling in the zebra finch brain.
Roeske TC, Scharff C, Olson CR, Nshdejan A, Mello CV. Roeske TC, et al. PLoS One. 2014 Nov 13;9(11):e111722. doi: 10.1371/journal.pone.0111722. eCollection 2014. PLoS One. 2014. PMID: 25393898 Free PMC article. - A species-specific view of song representation in a sensorimotor nucleus.
Alliende J, Lehongre K, Del Negro C. Alliende J, et al. J Physiol Paris. 2013 Jun;107(3):193-202. doi: 10.1016/j.jphysparis.2012.08.004. Epub 2012 Aug 30. J Physiol Paris. 2013. PMID: 22960663 Review. - Birth, migration, incorporation, and death of vocal control neurons in adult songbirds.
Alvarez-Buylla A, Kirn JR. Alvarez-Buylla A, et al. J Neurobiol. 1997 Nov;33(5):585-601. J Neurobiol. 1997. PMID: 9369461 Review.
Cited by
- Singing under the influence: examining the effects of nutrition and addiction on a learned vocal behavior.
Lovell PV, Olson CR, Mello CV. Lovell PV, et al. Mol Neurobiol. 2011 Oct;44(2):175-84. doi: 10.1007/s12035-011-8169-1. Epub 2011 Feb 23. Mol Neurobiol. 2011. PMID: 21340665 Free PMC article. Review. - Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.
Teramitsu I, Kudo LC, London SE, Geschwind DH, White SA. Teramitsu I, et al. J Neurosci. 2004 Mar 31;24(13):3152-63. doi: 10.1523/JNEUROSCI.5589-03.2004. J Neurosci. 2004. PMID: 15056695 Free PMC article. - Small molecule analysis and imaging of fatty acids in the zebra finch song system using time-of-flight-secondary ion mass spectrometry.
Amaya KR, Sweedler JV, Clayton DF. Amaya KR, et al. J Neurochem. 2011 Aug;118(4):499-511. doi: 10.1111/j.1471-4159.2011.07274.x. Epub 2011 May 19. J Neurochem. 2011. PMID: 21496023 Free PMC article. - Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury.
Duprey-Díaz MV, Blagburn JM, Blanco RE. Duprey-Díaz MV, et al. PLoS One. 2016 Sep 9;11(9):e0162626. doi: 10.1371/journal.pone.0162626. eCollection 2016. PLoS One. 2016. PMID: 27611191 Free PMC article. - Birdsong "transcriptomics": neurochemical specializations of the oscine song system.
Lovell PV, Clayton DF, Replogle KL, Mello CV. Lovell PV, et al. PLoS One. 2008;3(10):e3440. doi: 10.1371/journal.pone.0003440. Epub 2008 Oct 20. PLoS One. 2008. PMID: 18941504 Free PMC article.