Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13 - PubMed (original) (raw)

Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13

Y A Lee et al. Am J Hum Genet. 2000 Oct.

Abstract

Psoriasis is a common chronic inflammatory skin disease with a strong genetic component. Few psoriasis-susceptibility loci have been reported, and only two have been confirmed in independent data sets. This article reports results of a genomewide scan that was performed, using 370 microsatellite markers, for psoriasis-susceptibility loci in 32 German extended families, comprising 162 affected and 195 unaffected individuals. Nonparametric linkage analysis of all families provided strong evidence for a novel psoriasis-susceptibility locus on chromosome 19p (Zlr=3.50; P=.0002). Parametric analysis revealed a heterogeneity LOD score of 4.06, corresponding to a genomewide significance level of.037, under the assumption of a recessive model with high disease-allele frequency and 66% as the proportion of linked families. This study confirms linkage of psoriasis to the HLA region on chromosome 6p and suggests additional regions on chromosomes 8q and 21q for further investigations.

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Figures

Figure 1

Figure 1

Summary of the genome scan for psoriasis-susceptibility loci in 32 German extended families. The figure shows nonparametric multipoint GENEHUNTER PLUS _Z_lr (A) and LOD* score (B), across all autosomes, from pter to qter. Dotted lines indicate chromosome boundaries.

Figure 2

Figure 2

Linkage analysis on chromosome 19, showing GENEHUNTER nonparametric LOD* score (_Z_all) and HLOD score, assuming a recessive model with high disease-allele frequency, as well as GENEHUNTER PLUS _Z_lr and nonparametric LOD score. Markers are arranged in map order, according to the final Généthon human linkage map (Dib et al. 1996).

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References

Electronic-Database Information

    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/omim (for PSORS1 [MIM 177900], PSORS2 [MIM 602723], PSORS3 [MIM 601454], PSORS4 [MIM 603935], and PSORS5 [MIM 604316], respectively)
    1. GeneMap'99, http://www.ncbi.nlm.nih.gov/genemap/

References

    1. Abele DC, Dobson RL, Graham JB (1963) Heredity and psoriasis: study of a large family. Arch Dermatol 88:38–47 - PubMed
    1. Boehncke WH, Zollner TM, Dressel D, Kaufmann R (1997) Induction of psoriasiform inflammation by a bacterial superantigen in the SCID-hu xenogeneic transplantation model. J Cutan Pathol 24:1–7 - PubMed
    1. Brandrup F, Hauge M, Henningsen K, Eriksen B (1978) Psoriasis in an unselected series of twins. Arch Dermatol 114:874–878 - PubMed
    1. Capon F, Novelli G, Semprini S, Clementi M, Nudo M, Vultaggio P, Mazzanti C, Gobello T, Botta A, Fabrizi G, Dallapiccola B (1999) Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1. J Invest Dermatol 112:32–35 - PubMed
    1. Deloukas P, Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tome P, Hui L, Matise TC, McKusick KB, Beckmann JS, Bentolila S, Bihoreau M, Birren BB, Browne J, Butler A, Castle AB, Chiannilkulchai N, Clee C, Day PJ, Dehejia A, Dibling T, Drouot N, Duprat S, Fizames C, Bentley DR (1998) A physical map of 30,000 human genes. Science 282:744–746 - PubMed

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