Carbohydrate sulfotransferases in lymphocyte homing - PubMed (original) (raw)

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Carbohydrate sulfotransferases in lymphocyte homing

S Hemmerich et al. Glycobiology. 2000 Sep.

Abstract

Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.

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