Bioavailability of praziquantel increases with concomitant administration of food - PubMed (original) (raw)

Clinical Trial

Bioavailability of praziquantel increases with concomitant administration of food

N Castro et al. Antimicrob Agents Chemother. 2000 Oct.

Abstract

In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.

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Figures

FIG. 1

FIG. 1

Mean concentration in plasma (+standard error of the mean) of praziquantel in healthy volunteers treated with a single oral dose of 1,800 mg (three tablets of 600 mg) during fasting (●) or immediately after a high-fat (▵) or a high-carbohydrate (■) breakfast.

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