Dynamics of insulin secretion in obesity and diabetes - PubMed (original) (raw)
Review
. 2000 Jun:24 Suppl 2:S29-31.
doi: 10.1038/sj.ijo.0801273.
Affiliations
- PMID: 10997604
- DOI: 10.1038/sj.ijo.0801273
Review
Dynamics of insulin secretion in obesity and diabetes
K S Polonsky. Int J Obes Relat Metab Disord. 2000 Jun.
Abstract
Insulin resistance and compensatory hyperinsulinemia are commonly present in obesity. The biochemical mechanisms responsible for the maintenance of basal hypersecretion of insulin are reviewed in this article. Under basal, fasting and fed conditions the hyperinsulinemia of obesity largely depends on increased insulin secretion, without any alteration of the temporal secretion. This suggests that the functioning beta cell mass is enhanced, but normal regulatory mechanisms are maintained. A number of alterations in beta-cell function are present in conditions of impaired glucose tolerance which precede the onset of overt diabetes.
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