Rho family GTPases: more than simple switches - PubMed (original) (raw)

Review

Rho family GTPases: more than simple switches

M Symons et al. Trends Cell Biol. 2000 Oct.

Abstract

Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.

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