BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design - PubMed (original) (raw)
. 2000 Sep 21;43(19):3482-6.
doi: 10.1021/jm0002679.
P Chand, S Bantia, P Kotian, A Dehghani, Y El-Kattan, T H Lin, T L Hutchison, A J Elliott, C D Parker, S L Ananth, L L Horn, G W Laver, J A Montgomery
Affiliations
- PMID: 11000002
- DOI: 10.1021/jm0002679
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design
Y S Babu et al. J Med Chem. 2000.
No abstract available
Similar articles
- Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.
Chand P, Kotian PL, Dehghani A, El-Kattan Y, Lin TH, Hutchison TL, Babu YS, Bantia S, Elliott AJ, Montgomery JA. Chand P, et al. J Med Chem. 2001 Dec 6;44(25):4379-92. doi: 10.1021/jm010277p. J Med Chem. 2001. PMID: 11728184 - RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza.
Young D, Fowler C, Bush K. Young D, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1905-13. doi: 10.1098/rstb.2001.1004. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11779391 Free PMC article. Review. - The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.
Bromba CM, Mason JW, Brant MG, Chan T, Lunke MD, Petric M, Boulanger MJ, Wulff JE. Bromba CM, et al. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7137-41. doi: 10.1016/j.bmcl.2011.09.076. Epub 2011 Sep 24. Bioorg Med Chem Lett. 2011. PMID: 22001088 - Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Smith PW, Sollis SL, Howes PD, Cherry PC, Starkey ID, Cobley KN, Weston H, Scicinski J, Merritt A, Whittington A, Wyatt P, Taylor N, Green D, Bethell R, Madar S, Fenton RJ, Morley PJ, Pateman T, Beresford A. Smith PW, et al. J Med Chem. 1998 Mar 12;41(6):787-97. doi: 10.1021/jm970374b. J Med Chem. 1998. PMID: 9526555 - [Peramivir. A new and potent neuraminidase inhibitor for the treatment of influenza].
Reina J. Reina J. Rev Esp Quimioter. 2006 Dec;19(4):317-22. Rev Esp Quimioter. 2006. PMID: 17235399 Review. Spanish. No abstract available.
Cited by
- Retracted and republished from: "The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs".
Li Y, Huo S, Yin Z, Tian Z, Huang F, Liu P, Liu Y, Yu F. Li Y, et al. mBio. 2024 May 8;15(5):e0017524. doi: 10.1128/mbio.00175-24. Epub 2024 Mar 29. mBio. 2024. PMID: 38551343 Free PMC article. - Nitrene-transfer from azides to isocyanides: Unveiling its versatility as a promising building block for the synthesis of bioactive heterocycles.
Sawant DM, Joshi G, Ansari AJ. Sawant DM, et al. iScience. 2024 Feb 23;27(4):109311. doi: 10.1016/j.isci.2024.109311. eCollection 2024 Apr 19. iScience. 2024. PMID: 38510111 Free PMC article. Review. - Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins.
Li H, Fan W, Min J, Bai X, Yang W, Li H, Zhao Y, Lin R, Jia X, Liu W, Sun L. Li H, et al. iScience. 2023 Nov 23;26(12):108515. doi: 10.1016/j.isci.2023.108515. eCollection 2023 Dec 15. iScience. 2023. PMID: 38089580 Free PMC article. - A novel compound to overcome influenza drug resistance in endonuclease inhibitors.
Ren Y, Wan L, Cao S. Ren Y, et al. Mol Divers. 2024 Jun;28(3):1323-1333. doi: 10.1007/s11030-023-10659-x. Epub 2023 Jun 2. Mol Divers. 2024. PMID: 37268742 Free PMC article. - Co-infection of the respiratory epithelium, scene of complex functional interactions between viral, bacterial, and human neuraminidases.
Escuret V, Terrier O. Escuret V, et al. Front Microbiol. 2023 May 4;14:1137336. doi: 10.3389/fmicb.2023.1137336. eCollection 2023. Front Microbiol. 2023. PMID: 37213507 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Chemical Information