Selective activation of the fatty acid synthesis pathway in human prostate cancer - PubMed (original) (raw)
Comparative Study
Selective activation of the fatty acid synthesis pathway in human prostate cancer
J V Swinnen et al. Int J Cancer. 2000.
Abstract
A substantial subset of breast, colorectal, ovarian, endometrial and prostatic cancers displays markedly elevated expression of immunohistochemically detectable fatty acid synthase, a feature that has been associated with poor prognosis and that may be exploited in anti-neoplastic therapy. Here, using an RNA array hybridisation technique complemented by in situ hybridisation, we report that in prostate cancer fatty acid synthase expression is up-regulated at the mRNA level together with other enzymes of the same metabolic pathway. Contrary to the observations that in many cell systems (including androgen-stimulated LNCaP prostate cancer cells) fatty acid and cholesterol metabolism are co-ordinately regulated so as to supply balanced amounts of lipids for membrane biosynthesis, storage or secretion, no changes in the expression of genes involved in cholesterol synthesis were found. These findings point to selective activation of the fatty acid synthesis pathway and suggest a shift in the balance of lipogenic gene expression in a subgroup of prostate cancers.
Copyright 2000 Wiley-Liss, Inc.
Similar articles
- Androgens and the control of lipid metabolism in human prostate cancer cells.
Swinnen JV, Verhoeven G. Swinnen JV, et al. J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):191-8. doi: 10.1016/s0960-0760(97)00187-8. J Steroid Biochem Mol Biol. 1998. PMID: 9699873 Review. - Expression of human prostatic acid phosphatase and prostate specific antigen genes in neoplastic and benign tissues.
Sharief FS, Mohler JL, Sharief Y, Li SS. Sharief FS, et al. Biochem Mol Biol Int. 1994 Jun;33(3):567-74. Biochem Mol Biol Int. 1994. PMID: 7524903 - RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells.
Brusselmans K, De Schrijver E, Verhoeven G, Swinnen JV. Brusselmans K, et al. Cancer Res. 2005 Aug 1;65(15):6719-25. doi: 10.1158/0008-5472.CAN-05-0571. Cancer Res. 2005. PMID: 16061653 - Pattern and regulation of acetyl-CoA carboxylase gene expression.
Kim KH, Tae HJ. Kim KH, et al. J Nutr. 1994 Aug;124(8 Suppl):1273S-1283S. doi: 10.1093/jn/124.suppl_8.1273S. J Nutr. 1994. PMID: 7914919 Review.
Cited by
- Lipids and prostate cancer.
Suburu J, Chen YQ. Suburu J, et al. Prostaglandins Other Lipid Mediat. 2012 May;98(1-2):1-10. doi: 10.1016/j.prostaglandins.2012.03.003. Epub 2012 Apr 5. Prostaglandins Other Lipid Mediat. 2012. PMID: 22503963 Free PMC article. Review. - The fat side of prostate cancer.
Zadra G, Photopoulos C, Loda M. Zadra G, et al. Biochim Biophys Acta. 2013 Oct;1831(10):1518-32. doi: 10.1016/j.bbalip.2013.03.010. Epub 2013 Apr 2. Biochim Biophys Acta. 2013. PMID: 23562839 Free PMC article. Review. - Citrate-Induced p85α⁻PTEN Complex Formation Causes G2/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines.
Hung KC, Wang SG, Lin ML, Chen SS. Hung KC, et al. Int J Mol Sci. 2019 Apr 29;20(9):2105. doi: 10.3390/ijms20092105. Int J Mol Sci. 2019. PMID: 31035650 Free PMC article. - Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis.
Fang W, Cui H, Yu D, Chen Y, Wang J, Yu G. Fang W, et al. Med Oncol. 2014 Jul;31(7):15. doi: 10.1007/s12032-014-0015-7. Epub 2014 Jun 13. Med Oncol. 2014. PMID: 24924473 - Targeting lipid reprogramming in the tumor microenvironment by traditional Chinese medicines as a potential cancer treatment.
Zuo Q, Wu Y, Hu Y, Shao C, Liang Y, Chen L, Guo Q, Huang P, Chen Q. Zuo Q, et al. Heliyon. 2024 May 7;10(9):e30807. doi: 10.1016/j.heliyon.2024.e30807. eCollection 2024 May 15. Heliyon. 2024. PMID: 38765144 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical