Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat - PubMed (original) (raw)
Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat
E K Lambe et al. Cereb Cortex. 2000 Oct.
Abstract
The effect of serotonin (5-HT) on the release of glutamate was examined in pyramidal cells in layers II-VI of the frontal cortex. The intracellular recording electrode contained 1% biocytin so the neurons could later be visualized with an avidin-biotin peroxidase method. Pyramidal cells in layer V of the frontal cortex showed the greatest 5-HT-induced increase in both the frequency and amplitude of 'spontaneous' (non-electrically evoked) excitatory post-synaptic currents (EPSCs). A small proportion of neurons in layer II/III showed an increase in EPSC frequency, whereas cells in layer VI showed no significant change in either EPSC frequency or amplitude. The physiological response to 5-HT mirrors the high density of 5-HT(2A) receptors in layer V, as well as the pattern of thalamic projections in frontal cortex. The specific induction of EPSCs in layer V neurons suggests that 5-HT preferentially modulates the output neurons of the frontal cortex.
Similar articles
- Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.
Aghajanian GK, Marek GJ. Aghajanian GK, et al. Neuropharmacology. 1997 Apr-May;36(4-5):589-99. doi: 10.1016/s0028-3908(97)00051-8. Neuropharmacology. 1997. PMID: 9225284 - The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex.
Lambe EK, Aghajanian GK. Lambe EK, et al. J Neurosci. 2001 Dec 15;21(24):9955-63. doi: 10.1523/JNEUROSCI.21-24-09955.2001. J Neurosci. 2001. PMID: 11739602 Free PMC article. - Repeated blockade of 5-HT₇ receptors depresses glutamatergic transmission in the rat frontal cortex.
Tokarski K, Kusek M, Hess G. Tokarski K, et al. J Physiol Pharmacol. 2012 Apr;63(2):173-7. J Physiol Pharmacol. 2012. PMID: 22653904 - Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex.
Stutzmann GE, Marek GJ, Aghajanian GK. Stutzmann GE, et al. Neuroscience. 2001;105(1):55-69. doi: 10.1016/s0306-4522(01)00170-1. Neuroscience. 2001. PMID: 11483300 - The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis.
Marek GJ, Aghajanian GK. Marek GJ, et al. Biol Psychiatry. 1998 Dec 1;44(11):1118-27. doi: 10.1016/s0006-3223(98)00036-5. Biol Psychiatry. 1998. PMID: 9836015 Review.
Cited by
- Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression.
Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee HK, Huganir RL, Thompson SM. Cai X, et al. Nat Neurosci. 2013 Apr;16(4):464-72. doi: 10.1038/nn.3355. Epub 2013 Mar 17. Nat Neurosci. 2013. PMID: 23502536 Free PMC article. - Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors.
Jones RS, Woodhall GL. Jones RS, et al. J Physiol. 2005 Jan 1;562(Pt 1):107-20. doi: 10.1113/jphysiol.2004.076133. Epub 2004 Oct 21. J Physiol. 2005. PMID: 15498804 Free PMC article. Review. - Inhibition by 5-HT of the synaptic responses evoked by callosal fibers on cortical neurons in the mouse.
Troca-Marín JA, Geijo-Barrientos E. Troca-Marín JA, et al. Pflugers Arch. 2010 Nov;460(6):1073-85. doi: 10.1007/s00424-010-0875-4. Epub 2010 Sep 14. Pflugers Arch. 2010. PMID: 20838806 - Broadband cortical desynchronization underlies the human psychedelic state.
Muthukumaraswamy SD, Carhart-Harris RL, Moran RJ, Brookes MJ, Williams TM, Errtizoe D, Sessa B, Papadopoulos A, Bolstridge M, Singh KD, Feilding A, Friston KJ, Nutt DJ. Muthukumaraswamy SD, et al. J Neurosci. 2013 Sep 18;33(38):15171-83. doi: 10.1523/JNEUROSCI.2063-13.2013. J Neurosci. 2013. PMID: 24048847 Free PMC article. - Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex.
Yamamura S, Ohoyama K, Hamaguchi T, Kashimoto K, Nakagawa M, Kanehara S, Suzuki D, Matsumoto T, Motomura E, Shiroyama T, Okada M. Yamamura S, et al. Psychopharmacology (Berl). 2009 Oct;206(2):243-58. doi: 10.1007/s00213-009-1601-9. Epub 2009 Jul 3. Psychopharmacology (Berl). 2009. PMID: 19575183
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources