Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions - PubMed (original) (raw)

Review

. 2000 Oct 15;351 Pt 2(Pt 2):289-305.

Affiliations

• PMID: 11023813
• PMCID: PMC1221363

Review

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

W Kolch. Biochem J. 2000.

Abstract

The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-regulated kinase) pathway is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Although the basic regulatory steps have been elucidated, many features of this pathway are only beginning to emerge. This review focuses on the role of protein-protein interactions in the regulation of this pathway, and how they contribute to co-ordinate activation steps, subcellular redistribution, substrate phosphorylation and cross-talk with other signalling pathways.

PubMed Disclaimer

Similar articles

• Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.
  Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM. Yip-Schneider MT, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3. J Pharmacol Exp Ther. 2009. PMID: 19258520
• Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
  Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A. Sasaki A, et al. Nat Cell Biol. 2003 May;5(5):427-32. doi: 10.1038/ncb978. Nat Cell Biol. 2003. PMID: 12717443
• Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
  Chang F, Steelman LS, Shelton JG, Lee JT, Navolanic PM, Blalock WL, Franklin R, McCubrey JA. Chang F, et al. Int J Oncol. 2003 Mar;22(3):469-80. Int J Oncol. 2003. PMID: 12579299 Review.
• Coordinating ERK/MAPK signalling through scaffolds and inhibitors.
  Kolch W. Kolch W. Nat Rev Mol Cell Biol. 2005 Nov;6(11):827-37. doi: 10.1038/nrm1743. Nat Rev Mol Cell Biol. 2005. PMID: 16227978 Review.

Cited by

• Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line.
  Pudewell S, Wittich C, Kazemein Jasemi NS, Bazgir F, Ahmadian MR. Pudewell S, et al. Commun Biol. 2021 Jun 8;4(1):696. doi: 10.1038/s42003-021-02149-3. Commun Biol. 2021. PMID: 34103645 Free PMC article. Review.
• DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.
  Nguyen LK, Degasperi A, Cotter P, Kholodenko BN. Nguyen LK, et al. Sci Rep. 2015 Jul 29;5:12569. doi: 10.1038/srep12569. Sci Rep. 2015. PMID: 26220783 Free PMC article.
• Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.
  Wang XD, Wang Q, Chen XL, Huang JF, Yin Y, Da P, Wu H. Wang XD, et al. Mol Med Rep. 2015 Jul;12(1):865-70. doi: 10.3892/mmr.2015.3485. Epub 2015 Mar 13. Mol Med Rep. 2015. PMID: 25779928 Free PMC article.
• Kinase drug discovery 20 years after imatinib: progress and future directions.
  Cohen P, Cross D, Jänne PA. Cohen P, et al. Nat Rev Drug Discov. 2021 Jul;20(7):551-569. doi: 10.1038/s41573-021-00195-4. Epub 2021 May 17. Nat Rev Drug Discov. 2021. PMID: 34002056 Free PMC article. Review.
• E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway.
  Song L, Li H, Ma RR, Liu S, Zhang GH, Guo XY, Zhao RN, Wu XJ, Zhang K, Gao P. Song L, et al. Cell Death Dis. 2022 Nov 21;13(11):982. doi: 10.1038/s41419-022-05414-3. Cell Death Dis. 2022. PMID: 36414640 Free PMC article.

References

1. 1. Cancer Res. 1999 Jun 15;59(12):2815-9 - PubMed
2. 1. Mol Cell Biol. 1999 Aug;19(8):5523-34 - PubMed
3. 1. Chem Biol. 1999 Aug;6(8):559-68 - PubMed
4. 1. Pharmacol Ther. 1999 May-Jun;82(2-3):303-13 - PubMed
5. 1. Mol Cell Biol. 1999 Sep;19(9):6057-64 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal