The dual origin of the yeast mitochondrial proteome - PubMed (original) (raw)

The dual origin of the yeast mitochondrial proteome

O Karlberg et al. Yeast. 2000.

Abstract

We propose a scheme for the origin of mitochondria based on phylogenetic reconstructions with more than 400 yeast nuclear genes that encode mitochondrial proteins. Half of the yeast mitochondrial proteins have no discernable bacterial homologues, while one-tenth are unequivocally of alpha-proteobacterial origin. These data suggest that the majority of genes encoding yeast mitochondrial proteins are descendants of two different genomic lineages that have evolved in different modes. First, the ancestral free-living alpha-proteobacterium evolved into an endosymbiont of an anaerobic host. Most of the ancestral bacterial genes were lost, but a small fraction of genes supporting bioenergetic and translational processes were retained and eventually transferred to what became the host nuclear genome. In a second, parallel mode, a larger number of novel mitochondrial genes were recruited from the nuclear genome to complement the remaining genes from the bacterial ancestor. These eukaryotic genes, which are primarily involved in transport and regulatory functions, transformed the endosymbiont into an ATP-exporting organelle.

Copyright 2000 John Wiley & Sons, Ltd.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Mol Biol Evol. 1987 Jul;4(4):406-25 - PubMed
    1. Int Rev Cytol. 1992;141:233-357 - PubMed
    1. FEBS Lett. 1994 Mar 21;341(2-3):146-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2328-32 - PubMed
    1. Nature. 1997 May 29;387(6632):493-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources