Dynamin and its role in membrane fission - PubMed (original) (raw)

Review

Dynamin and its role in membrane fission

J E Hinshaw. Annu Rev Cell Dev Biol. 2000.

Abstract

Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and possibly vesicle trafficking in and out of the Golgi. In addition to the GTPase domain, dynamin also contains a pleckstrin homology domain (PH) implicated in membrane binding, a GTPase effector domain (GED) shown to be essential for self-assembly and stimulated GTPase activity, and a C-terminal proline-rich domain (PRD), which contains several SH3-binding sites. Dynamin partners bind to the PRD and may either stimulate dynamin's GTPase activity or target dynamin to the plasma membrane. Purified dynamin readily self-assembles into rings or spirals. This striking structural property supports the hypothesis that dynamin wraps around the necks of budding vesicles where it plays a key role in membrane fission. The focus of this review is on the relationship between the GTPase and self-assembly properties of dynamin and its cellular function.

PubMed Disclaimer

Cited by

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1.
Razidlo GL, Wang Y, Chen J, Krueger EW, Billadeau DD, McNiven MA. Razidlo GL, et al. Dev Cell. 2013 Mar 25;24(6):573-85. doi: 10.1016/j.devcel.2013.02.010. Dev Cell. 2013. PMID: 23537630 Free PMC article.
Receptors and Host Factors for Enterovirus Infection: Implications for Cancer Therapy.
Alekseeva ON, Hoa LT, Vorobyev PO, Kochetkov DV, Gumennaya YD, Naberezhnaya ER, Chuvashov DO, Ivanov AV, Chumakov PM, Lipatova AV. Alekseeva ON, et al. Cancers (Basel). 2024 Sep 12;16(18):3139. doi: 10.3390/cancers16183139. Cancers (Basel). 2024. PMID: 39335111 Free PMC article. Review.
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Gong C, Zhang J, Zhang L, Wang Y, Ma H, Wu W, Cui J, Wang Y, Ren Z. Gong C, et al. Am J Cancer Res. 2015 Jan 15;5(2):702-13. eCollection 2015. Am J Cancer Res. 2015. PMID: 25973308 Free PMC article.
Event-triggered STED imaging.
Alvelid J, Damenti M, Sgattoni C, Testa I. Alvelid J, et al. Nat Methods. 2022 Oct;19(10):1268-1275. doi: 10.1038/s41592-022-01588-y. Epub 2022 Sep 8. Nat Methods. 2022. PMID: 36076037 Free PMC article.
Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.
Guo J, Wenk MR, Pellegrini L, Onofri F, Benfenati F, De Camilli P. Guo J, et al. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3995-4000. doi: 10.1073/pnas.0230488100. Epub 2003 Mar 19. Proc Natl Acad Sci U S A. 2003. PMID: 12646710 Free PMC article.

Dynamin and its role in membrane fission - PubMed (original) (raw)