Endogenous opioids and reward - PubMed (original) (raw)
Review
Endogenous opioids and reward
J M Van Ree et al. Eur J Pharmacol. 2000.
Abstract
The discovery of endogenous opioids has markedly influenced the research on the biology of addiction and reward brain processes. Evidence has been presented that these brain substances modulate brain stimulation reward, self-administration of different drugs of abuse, sexual behaviour and social behaviour. There appears to be two different domains in which endogenous opioids, present in separate and distinct brain regions, are involved. One is related to the modulation of incentive motivational processes and the other to the performance of certain behaviours. It is concluded that endogenous opioids may play a role in the vulnerability to certain diseases, such as addiction and autism, but also when the disease is present, such as alcoholism.
Similar articles
- Introduction to symposium on endorphins and behavioural processes; review of literature on endorphins and exercise.
Steinberg H, Sykes EA. Steinberg H, et al. Pharmacol Biochem Behav. 1985 Nov;23(5):857-62. doi: 10.1016/0091-3057(85)90083-8. Pharmacol Biochem Behav. 1985. PMID: 3909168 Review. - The physiology of opiate hedonic effects and the role of opioids in motivated behavior.
Carr KD. Carr KD. Adv Alcohol Subst Abuse. 1984 Spring;3(3):5-18. doi: 10.1300/J251v03n03_02. Adv Alcohol Subst Abuse. 1984. PMID: 6388274 Review. - Brain endorphins: possible mediators of pleasure and reward.
Stein L. Stein L. Neurosci Res Program Bull. 1978 Dec;16(4):556-63. Neurosci Res Program Bull. 1978. PMID: 220556 No abstract available. - [The endogenous opioid system and drug addiction].
Maldonado R. Maldonado R. Ann Pharm Fr. 2010 Jan;68(1):3-11. doi: 10.1016/j.pharma.2009.12.001. Epub 2010 Jan 21. Ann Pharm Fr. 2010. PMID: 20176158 Free PMC article. Review. French. - Brain endorphins: possible role in reward and memory formation.
Stein L, Belluzzi JD. Stein L, et al. Fed Proc. 1979 Oct;38(11):2468-72. Fed Proc. 1979. PMID: 39791
Cited by
- Endocannabinoid system involvement in brain reward processes related to drug abuse.
Solinas M, Yasar S, Goldberg SR. Solinas M, et al. Pharmacol Res. 2007 Nov;56(5):393-405. doi: 10.1016/j.phrs.2007.09.005. Epub 2007 Sep 8. Pharmacol Res. 2007. PMID: 17936009 Free PMC article. Review. - Activation of delta-opioid receptors reduces excitatory input to putative gustatory cells within the nucleus of the solitary tract.
Zhu M, Cho YK, Li CS. Zhu M, et al. J Neurophysiol. 2009 Jan;101(1):258-68. doi: 10.1152/jn.90648.2008. Epub 2008 Nov 19. J Neurophysiol. 2009. PMID: 19019978 Free PMC article. - Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans.
Lee MR, Gallen CL, Zhang X, Hodgkinson CA, Goldman D, Stein EA, Barr CS. Lee MR, et al. PLoS One. 2011;6(9):e24203. doi: 10.1371/journal.pone.0024203. Epub 2011 Sep 2. PLoS One. 2011. PMID: 21912675 Free PMC article. - OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.
Schwandt ML, Lindell SG, Higley JD, Suomi SJ, Heilig M, Barr CS. Schwandt ML, et al. Psychoneuroendocrinology. 2011 Oct;36(9):1303-11. doi: 10.1016/j.psyneuen.2011.03.002. Epub 2011 Apr 3. Psychoneuroendocrinology. 2011. PMID: 21459516 Free PMC article. - Topography of social touching depends on emotional bonds between humans.
Suvilehto JT, Glerean E, Dunbar RI, Hari R, Nummenmaa L. Suvilehto JT, et al. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13811-6. doi: 10.1073/pnas.1519231112. Epub 2015 Oct 26. Proc Natl Acad Sci U S A. 2015. PMID: 26504228 Free PMC article.