Allelic variation in a peptide-inducible two-component system of Streptococcus pneumoniae - PubMed (original) (raw)

Allelic variation in a peptide-inducible two-component system of Streptococcus pneumoniae

P Reichmann et al. FEMS Microbiol Lett. 2000.

Abstract

The peptide SpiP of Streptococcus pneumoniae regulates the induction of a complex signal transduction system spiR1spiR2spiH. Distinct alleles of spiP and the receptor histidine protein kinase gene spiH were recognized in different pneumococcal clones. The spi system in strain KNR7/87 is adjacent to a bacteriocin gene cluster encoding putative double glycine-type bacteriocins, immunity proteins, and translocator proteins. A direct repeat element upstream of the spiR1 promoter and another three potential transcription start sites within the bacteriocin cluster indicate that SpiP functions as an inducing peptide for bacteriocin synthesis in S. pneumoniae.

PubMed Disclaimer

Similar articles

• An electrostatic interaction between BlpC and BlpH dictates pheromone specificity in the control of bacteriocin production and immunity in Streptococcus pneumoniae.
  Pinchas MD, LaCross NC, Dawid S. Pinchas MD, et al. J Bacteriol. 2015 Apr;197(7):1236-48. doi: 10.1128/JB.02432-14. Epub 2015 Jan 26. J Bacteriol. 2015. PMID: 25622617 Free PMC article.
• Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.
  de Saizieu A, Gardès C, Flint N, Wagner C, Kamber M, Mitchell TJ, Keck W, Amrein KE, Lange R. de Saizieu A, et al. J Bacteriol. 2000 Sep;182(17):4696-703. doi: 10.1128/JB.182.17.4696-4703.2000. J Bacteriol. 2000. PMID: 10940007 Free PMC article.
• Diverse Ecological Strategies Are Encoded by Streptococcus pneumoniae Bacteriocin-Like Peptides.
  Miller EL, Abrudan MI, Roberts IS, Rozen DE. Miller EL, et al. Genome Biol Evol. 2016 Apr 13;8(4):1072-90. doi: 10.1093/gbe/evw055. Genome Biol Evol. 2016. PMID: 26983823 Free PMC article.
• Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment.
  Gómez-Mejia A, Gámez G, Hammerschmidt S. Gómez-Mejia A, et al. Int J Med Microbiol. 2018 Aug;308(6):722-737. doi: 10.1016/j.ijmm.2017.11.012. Epub 2017 Nov 26. Int J Med Microbiol. 2018. PMID: 29221986 Review.
• Role of two-component systems in the virulence of Streptococcus pneumoniae.
  Paterson GK, Blue CE, Mitchell TJ. Paterson GK, et al. J Med Microbiol. 2006 Apr;55(Pt 4):355-363. doi: 10.1099/jmm.0.46423-0. J Med Microbiol. 2006. PMID: 16533981 Review.

Cited by

• BlpC-mediated selfish program leads to rapid loss of Streptococcus pneumoniae clonal diversity during infection.
  Aggarwal SD, Lees JA, Jacobs NT, Bee GCW, Abruzzo AR, Weiser JN. Aggarwal SD, et al. Cell Host Microbe. 2023 Jan 11;31(1):124-134.e5. doi: 10.1016/j.chom.2022.10.015. Epub 2022 Nov 16. Cell Host Microbe. 2023. PMID: 36395758 Free PMC article.
• The Outer Surface Protease, SepM, Is Required for blp Locus Activation in Three of the Four Most Common Pherotypes of Streptococcus pneumoniae.
  Ratner S, Bollinger K, Richardson J, Dawid S. Ratner S, et al. J Bacteriol. 2022 Nov 15;204(11):e0019622. doi: 10.1128/jb.00196-22. Epub 2022 Oct 26. J Bacteriol. 2022. PMID: 36286514 Free PMC article.
• Epidemiological dynamics of bacteriocin competition and antibiotic resistance.
  Lehtinen S, Croucher NJ, Blanquart F, Fraser C. Lehtinen S, et al. Proc Biol Sci. 2022 Oct 12;289(1984):20221197. doi: 10.1098/rspb.2022.1197. Epub 2022 Oct 5. Proc Biol Sci. 2022. PMID: 36196547 Free PMC article.
• The pneumococcal social network.
  Aggarwal SD, Yesilkaya H, Dawid S, Hiller NL. Aggarwal SD, et al. PLoS Pathog. 2020 Oct 29;16(10):e1008931. doi: 10.1371/journal.ppat.1008931. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33119698 Free PMC article. Review.
• Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems.
  Wang J, Li JW, Li J, Huang Y, Wang S, Zhang JR. Wang J, et al. PLoS Pathog. 2020 Mar 18;16(3):e1008417. doi: 10.1371/journal.ppat.1008417. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32187228 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Molecular Biology Databases

  • BioCyc