Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone - PubMed (original) (raw)
Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone
J C Conover et al. Nat Neurosci. 2000 Nov.
Abstract
The subventricular zone (SVZ) of the lateral ventricles, the largest remaining germinal zone of the adult mammalian brain, contains an extensive network of neuroblasts migrating rostrally to the olfactory bulb. Little is known about the endogenous proliferation signals for SVZ neural stem cells or guidance cues along the migration pathway. Here we show that the receptor tyrosine kinases EphB1-3 and EphA4 and their transmembrane ligands, ephrins-B2/3, are expressed by cells of the SVZ. Electron microscopy revealed ephrin-B ligands associated with SVZ astrocytes, which function as stem cells in this germinal zone. A three-day infusion of the ectodomain of either EphB2 or ephrin-B2 into the lateral ventricle disrupted migration of neuroblasts and increased cell proliferation. These results suggest that Eph/ephrin signaling is involved in the migration of neuroblasts in the adult SVZ and in either direct or indirect regulation of cell proliferation.
Similar articles
- Complementary and layered expression of Ephs and ephrins in developing mouse inner ear.
Pickles JO, Claxton C, Van Heumen WR. Pickles JO, et al. J Comp Neurol. 2002 Jul 29;449(3):207-16. doi: 10.1002/cne.10231. J Comp Neurol. 2002. PMID: 12115675 - Eph receptors and ephrins restrict cell intermingling and communication.
Mellitzer G, Xu Q, Wilkinson DG. Mellitzer G, et al. Nature. 1999 Jul 1;400(6739):77-81. doi: 10.1038/21907. Nature. 1999. PMID: 10403252 - Roles of Eph receptors and ephrins in segmental patterning.
Xu Q, Mellitzer G, Wilkinson DG. Xu Q, et al. Philos Trans R Soc Lond B Biol Sci. 2000 Jul 29;355(1399):993-1002. doi: 10.1098/rstb.2000.0635. Philos Trans R Soc Lond B Biol Sci. 2000. PMID: 11128993 Free PMC article. Review. - Interaction of EphB2-tyrosine kinase receptor and its ligand conveys dorsalization signal in Xenopus laevis development.
Tanaka M, Wang DY, Kamo T, Igarashi H, Wang Y, Xiang YY, Tanioka F, Naito Y, Sugimura H. Tanaka M, et al. Oncogene. 1998 Sep 24;17(12):1509-16. doi: 10.1038/sj.onc.1202068. Oncogene. 1998. PMID: 9794228 - Regulation of angiogenesis by Eph-ephrin interactions.
Kuijper S, Turner CJ, Adams RH. Kuijper S, et al. Trends Cardiovasc Med. 2007 Jul;17(5):145-51. doi: 10.1016/j.tcm.2007.03.003. Trends Cardiovasc Med. 2007. PMID: 17574121 Review.
Cited by
- Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling.
Shin HY, Han KS, Park HW, Hong YH, Kim Y, Moon HE, Park KW, Park HR, Lee CJ, Lee K, Kim SJ, Heo MS, Park SH, Kim DG, Paek SH. Shin HY, et al. Exp Neurobiol. 2021 Apr 30;30(2):120-143. doi: 10.5607/en21004. Exp Neurobiol. 2021. PMID: 33972466 Free PMC article. - Spatiotemporal changes to the subventricular zone stem cell pool through aging.
Shook BA, Manz DH, Peters JJ, Kang S, Conover JC. Shook BA, et al. J Neurosci. 2012 May 16;32(20):6947-56. doi: 10.1523/JNEUROSCI.5987-11.2012. J Neurosci. 2012. PMID: 22593063 Free PMC article. - Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling.
Ashton RS, Conway A, Pangarkar C, Bergen J, Lim KI, Shah P, Bissell M, Schaffer DV. Ashton RS, et al. Nat Neurosci. 2012 Oct;15(10):1399-406. doi: 10.1038/nn.3212. Epub 2012 Sep 16. Nat Neurosci. 2012. PMID: 22983209 Free PMC article. - Subventricular zone progenitors in time and space: generating neuronal diversity.
Sequerra EB. Sequerra EB. Front Cell Neurosci. 2014 Dec 22;8:434. doi: 10.3389/fncel.2014.00434. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25565967 Free PMC article. Review. - Lessons from the embryonic neural stem cell niche for neural lineage differentiation of pluripotent stem cells.
Solozobova V, Wyvekens N, Pruszak J. Solozobova V, et al. Stem Cell Rev Rep. 2012 Sep;8(3):813-29. doi: 10.1007/s12015-012-9381-8. Stem Cell Rev Rep. 2012. PMID: 22628111 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous