Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses - PubMed (original) (raw)
. 2000 Nov;3(11):1107-12.
doi: 10.1038/80624.
Affiliations
- PMID: 11036267
- DOI: 10.1038/80624
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses
V Y Bolshakov et al. Nat Neurosci. 2000 Nov.
Abstract
Although the function of the p42/p44 mitogen-activated protein (MAP) kinase pathway in long-term potentiation at hippocampal CA3-CA1 synapses has been well described, relatively little is known about the importance of the p38 MAP kinase pathway in synaptic plasticity. Here we show that the p38 MAP kinase pathway, a parallel signaling cascade activated by distinct upstream kinases, mediates the induction of metabotropic glutamate receptor-dependent long-term depression at CA3-CA1 synapses. Thus, two parallel MAP kinase pathways contribute to opposing forms of long-term plasticity at a central synapse.
Similar articles
- Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus.
Lanté F, de Jésus Ferreira MC, Guiramand J, Récasens M, Vignes M. Lanté F, et al. Hippocampus. 2006;16(4):345-60. doi: 10.1002/hipo.20146. Hippocampus. 2006. PMID: 16302229 - Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.
McCutchen E, Scheiderer CL, Dobrunz LE, McMahon LL. McCutchen E, et al. J Neurophysiol. 2006 Dec;96(6):3114-21. doi: 10.1152/jn.00144.2006. Epub 2006 Sep 27. J Neurophysiol. 2006. PMID: 17005622 - Mechanisms underlying dedepression of synaptic NMDA receptors in the hippocampus.
Morishita W, Malenka RC. Morishita W, et al. J Neurophysiol. 2008 Jan;99(1):254-63. doi: 10.1152/jn.01011.2007. Epub 2007 Nov 7. J Neurophysiol. 2008. PMID: 17989241 - Scaffolding and protein interactions in MAP kinase modules.
Karandikar M, Cobb MH. Karandikar M, et al. Cell Calcium. 1999 Nov;26(5):219-26. doi: 10.1054/ceca.1999.0074. Cell Calcium. 1999. PMID: 10643560 Review. - [Functional analysis of molecules involved in synaptic plasticity in the cerebellum].
Aiba A. Aiba A. Tanpakushitsu Kakusan Koso. 2008 Mar;53(4 Suppl):544-8. Tanpakushitsu Kakusan Koso. 2008. PMID: 21089334 Review. Japanese. No abstract available.
Cited by
- Effects of Cannabis on Glutamatergic Neurotransmission: The Interplay between Cannabinoids and Glutamate.
Chowdhury KU, Holden ME, Wiley MT, Suppiramaniam V, Reed MN. Chowdhury KU, et al. Cells. 2024 Jun 29;13(13):1130. doi: 10.3390/cells13131130. Cells. 2024. PMID: 38994982 Free PMC article. Review. - Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking.
Fanous S, Guez-Barber DH, Goldart EM, Schrama R, Theberge FR, Shaham Y, Hope BT. Fanous S, et al. J Neurochem. 2013 Jan;124(1):100-8. doi: 10.1111/jnc.12074. Epub 2012 Nov 21. J Neurochem. 2013. PMID: 23113797 Free PMC article. - Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.
Banko JL, Hou L, Poulin F, Sonenberg N, Klann E. Banko JL, et al. J Neurosci. 2006 Feb 22;26(8):2167-73. doi: 10.1523/JNEUROSCI.5196-05.2006. J Neurosci. 2006. PMID: 16495443 Free PMC article. - Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria.
Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, Chavkin C. Bruchas MR, et al. J Neurosci. 2007 Oct 24;27(43):11614-23. doi: 10.1523/JNEUROSCI.3769-07.2007. J Neurosci. 2007. PMID: 17959804 Free PMC article. - Long-term depression in the adult hippocampus in vivo involves activation of extracellular signal-regulated kinase and phosphorylation of Elk-1.
Thiels E, Kanterewicz BI, Norman ED, Trzaskos JM, Klann E. Thiels E, et al. J Neurosci. 2002 Mar 15;22(6):2054-62. doi: 10.1523/JNEUROSCI.22-06-02054.2002. J Neurosci. 2002. PMID: 11896145 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous