Fibrogenesis. V. TGF-beta signaling pathways - PubMed (original) (raw)

Review

. 2000 Nov;279(5):G845-50.

doi: 10.1152/ajpgi.2000.279.5.G845.

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• PMID: 11052979
• DOI: 10.1152/ajpgi.2000.279.5.G845

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Review

Fibrogenesis. V. TGF-beta signaling pathways

R G Wells. Am J Physiol Gastrointest Liver Physiol. 2000 Nov.

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Abstract

Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years, but factors that determine the nature of the TGF-beta response are poorly understood. In particular, signaling pathways that specifically mediate the matrix effects of TGF-beta have received little attention, although they will be important therapeutic targets in the treatment of pathological fibrosis. This themes article focuses on TGF-beta signaling and highlights potential points for generating matrix-specific responses.

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