Signaling networks: the origins of cellular multitasking - PubMed (original) (raw)

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Signaling networks: the origins of cellular multitasking

J D Jordan et al. Cell. 2000.

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Figure 1

Figure 1

Adenylyl Cyclases as Examples of a Junction The signal receiving capabilities of the various adenylyl cyclase isoforms and the capability of the cAMP-dependent protein kinase (PKA) to regulate various physiological functions are shown. Receptor channel, ligand gated channel (e.g., NMDA receptor); RTK, receptor tyrosine kinase; GPCR, G protein–coupled receptor. Stimulatory signals are shown as arrows and inhibitory signals as plungers. The various cellular components or processes regulated by PKA are shown in the red ovals and the resultant physiological functions are given below.

Figure 2

Figure 2

Cdc42, a Member of the Rho Family of GTPases as an Example of a Node Cdc42 may be stimulated both by receptor-tyrosine kinases (RTK) as well as G protein–coupled receptors (GPCR), and in turn regulate different cellular functions by regulating the distinct downstream kinases Pak, S6K (S6-kinase), or the serum response factor (SRF).

Figure 3

Figure 3

Postulated Postsynaptic Signaling Network in the CA1 Pyramidal Neuron A simplified version of some of the key elements of the network and its interface with the various cellular machinery is shown. The purpose of the two figures is to highlight the interconnections between the key protein kinases within the network and the different cellular machinery. In both figures signal flow from the receptor through signal transducers and second messengers is shown in gray. The black arrows denote connections between the various cellular machinery. Panel (A) highlights the connections between the different kinases and the various cellular machinery. It can be readily seen that each protein kinase in the network can regulate multiple cellular machinery. Panel (B) highlights the view from the cellular machinery perspective to indicate that most cellular machines are regulated by multiple protein kinases. It is predicted that such meshing results in a system in which multiple machinery can be coordinately regulated by the signaling network in a robust manner.

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