Signaling events during swelling and regulatory volume decrease - PubMed (original) (raw)

Review

. 2000 Oct;25(9-10):1301-14.

doi: 10.1023/a:1007652330703.

Affiliations

• PMID: 11059803
• DOI: 10.1023/a:1007652330703

Review

Signaling events during swelling and regulatory volume decrease

H Pasantes-Morales et al. Neurochem Res. 2000 Oct.

Abstract

Brain cell swelling compromises neuronal function and survival by the risk of generation of ischemia episodes as compression of small vessels occurs due to the limits to expansion imposed by the rigid skull. External osmolarity reductions or intracellular accumulation of osmotically active solutes result in cell swelling which can be counteracted by extrusion of osmolytes through specific efflux pathways. Characterization of these pathways has received considerable attention, and there is now interest in the understanding of the intracellular signaling events involved in their activation and regulation. Calcium and calmodulin, phosphoinositides and cAMP may act as second messengers, carrying the information about a cell volume change into signaling enzymes. Small GTPases, protein tyrosine kinases and phospholipases, also appear to be part of the signaling cascades ultimately modulating the osmolyte efflux pathways. This review focus on i) the influence of hyposmotic and isosmotic swelling on these signaling events and molecules and ii) the effects of manipulating their function on the osmolyte fluxes, particularly K+, CI- and amino acids, and on the consequent efficiency of cell volume adjustment.

PubMed Disclaimer

Similar articles

• Amino acid osmolytes in regulatory volume decrease and isovolumetric regulation in brain cells: contribution and mechanisms.
  Pasantes-Morales H, Franco R, Torres-Marquez ME, Hernández-Fonseca K, Ortega A. Pasantes-Morales H, et al. Cell Physiol Biochem. 2000;10(5-6):361-70. doi: 10.1159/000016369. Cell Physiol Biochem. 2000. PMID: 11125217 Review.
• Mechanisms sensing and modulating signals arising from cell swelling.
  Jakab M, Fürst J, Gschwentner M, Bottà G, Garavaglia ML, Bazzini C, Rodighiero S, Meyer G, Eichmueller S, Wöll E, Chwatal S, Ritter M, Paulmichl M. Jakab M, et al. Cell Physiol Biochem. 2002;12(5-6):235-58. doi: 10.1159/000067895. Cell Physiol Biochem. 2002. PMID: 12438761 Review.
• Volume changes in neurons: hyperexcitability and neuronal death.
  Pasantes-Morales H, Tuz K. Pasantes-Morales H, et al. Contrib Nephrol. 2006;152:221-240. doi: 10.1159/000096326. Contrib Nephrol. 2006. PMID: 17065815 Review.
• Activation and inactivation of taurine efflux in hyposmotic and isosmotic swelling in cortical astrocytes: role of ionic strength and cell volume decrease.
  Cardin V, Peña-Segura C, Pasantes-Morales H. Cardin V, et al. J Neurosci Res. 1999 Jun 15;56(6):659-67. doi: 10.1002/(SICI)1097-4547(19990615)56:6<659::AID-JNR12>3.0.CO;2-W. J Neurosci Res. 1999. PMID: 10374821
• Mechanisms counteracting swelling in brain cells during hyponatremia.
  Pasantes-Morales H, Franco R, Ordaz B, Ochoa LD. Pasantes-Morales H, et al. Arch Med Res. 2002 May-Jun;33(3):237-44. doi: 10.1016/s0188-4409(02)00353-3. Arch Med Res. 2002. PMID: 12031627 Review.

Cited by

• Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
  Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK. Bhattacharjee A, et al. J Neurosci. 2003 Dec 17;23(37):11681-91. doi: 10.1523/JNEUROSCI.23-37-11681.2003. J Neurosci. 2003. PMID: 14684870 Free PMC article.
• Volume-dependent osmolyte efflux from neural tissues: regulation by G-protein-coupled receptors.
  Fisher SK, Cheema TA, Foster DJ, Heacock AM. Fisher SK, et al. J Neurochem. 2008 Sep;106(5):1998-2014. doi: 10.1111/j.1471-4159.2008.05510.x. Epub 2008 Jun 2. J Neurochem. 2008. PMID: 18518929 Free PMC article. Review.
• The role of ion channels in malignant brain tumors.
  Simon OJ, Müntefering T, Grauer OM, Meuth SG. Simon OJ, et al. J Neurooncol. 2015 Nov;125(2):225-35. doi: 10.1007/s11060-015-1896-9. Epub 2015 Sep 3. J Neurooncol. 2015. PMID: 26334315 Review.
• Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
  Belsey MJ, Davies AR, Witchel HJ, Kozlowski RZ. Belsey MJ, et al. Neurochem Res. 2007 Nov;32(11):1940-9. doi: 10.1007/s11064-007-9389-7. Epub 2007 Jun 12. Neurochem Res. 2007. PMID: 17562164
• Regulatory volume decrease after swelling induced by urea in fibroblasts: prominent role of organic osmolytes.
  López-Domínguez A, Ramos-Mandujano G, Vázquez-Juárez E, Pasantes-Morales H. López-Domínguez A, et al. Mol Cell Biochem. 2007 Dec;306(1-2):95-104. doi: 10.1007/s11010-007-9558-7. Epub 2007 Aug 8. Mol Cell Biochem. 2007. PMID: 17684706

References

1. 1. Pflugers Arch. 1996 Jan;431(3):467-9 - PubMed
2. 1. J Neurophysiol. 1998 Mar;79(3):1441-9 - PubMed
3. 1. Biophys J. 1995 May;68(5):1888-94 - PubMed
4. 1. Am J Physiol. 1999 Sep;277(3 Pt 1):C392-402 - PubMed
5. 1. Pflugers Arch. 1999 Jan;437(2):227-34 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.