Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1 - PubMed (original) (raw)
Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1
M Z Limongi et al. Cytogenet Cell Genet. 2000.
Abstract
In this study we have used FISH to examine the relationship between a group of homeobox genes, namely DLX1/DLX2, EVX2 and four HOXD genes (10, 11, 12, 13), that map to region q31 on chromosome 2, and the FRA2G and FRA2H fragile sites located at 2q31 and 2q32.1 respectively. Our results indicate that these homeobox genes lie between the two fragile regions.
Copyright 2000 S. Karger AG, Basel.
Similar articles
- Cytogenetic mapping of five YAC clones to human chromosome region 2q31 --> q32.1 in relation to the FRA2G common fragile site.
Pelliccia F, Limongi MZ, Gaddini L, Russo MT, Rocchi A. Pelliccia F, et al. Genetica. 2002 Aug;115(3):269-72. doi: 10.1023/a:1020670625199. Genetica. 2002. PMID: 12440566 - Order of six loci at 2q24-q31 and orientation of the HOXD locus.
Rossi E, Faiella A, Zeviani M, Labeit S, Floridia G, Brunelli S, Cammarata M, Boncinelli E, Zuffardi O. Rossi E, et al. Genomics. 1994 Nov 1;24(1):34-40. doi: 10.1006/geno.1994.1579. Genomics. 1994. PMID: 7896287 - Common fragile genes.
Matsuyama A, Croce CM, Huebner K. Matsuyama A, et al. Eur J Histochem. 2004;48(1):29-36. Eur J Histochem. 2004. PMID: 15145773 Review. - Genetic alterations in cancer as a result of breakage at fragile sites.
Popescu NC. Popescu NC. Cancer Lett. 2003 Mar 20;192(1):1-17. doi: 10.1016/s0304-3835(02)00596-7. Cancer Lett. 2003. PMID: 12637148 Review.
Cited by
- Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?
Georgakilas AG, Tsantoulis P, Kotsinas A, Michalopoulos I, Townsend P, Gorgoulis VG. Georgakilas AG, et al. Cell Mol Life Sci. 2014 Dec;71(23):4519-44. doi: 10.1007/s00018-014-1717-x. Epub 2014 Sep 20. Cell Mol Life Sci. 2014. PMID: 25238782 Free PMC article. Review. - A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly.
Goodman FR, Majewski F, Collins AL, Scambler PJ. Goodman FR, et al. Am J Hum Genet. 2002 Feb;70(2):547-55. doi: 10.1086/338921. Epub 2002 Jan 3. Am J Hum Genet. 2002. PMID: 11778160 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases
Research Materials