Evidence for a high ancestral GC content in Drosophila - PubMed (original) (raw)
Evidence for a high ancestral GC content in Drosophila
F Rodríguez-Trelles et al. Mol Biol Evol. 2000 Nov.
Abstract
Study of the nucleotide composition in Drosophila, focusing on the saltans and willistoni groups, has revealed unanticipated differences in nucleotide composition among lineages. Compositional differences are associated with an accelerated rate of nucleotide substitution in functionally less constrained regions. These observations have been set forth against the extended opinion that the pattern of point mutation has remained constant during the evolution of the genus. A crucial assumption has been that the most recent common ancestor of the subgenus Sophophora had an elevated GC content. Until now, this assumption has been supported by indirect arguments, consisting of extrapolations from closely related outgroups and limited by the robustness of mathematical descriptions concerning the extensive nucleotide composition differences among sequences. The present study seeks to test the assumption of a high ancestral GC content using realistic representations of the nucleotide substitution process to account for potential biases induced by the heterogeneous GC content of the taxa. The analysis of eight nuclear genes unambiguously corroborates that the common ancestor of Sophophora had an elevated GC content.
Similar articles
- Switch in codon bias and increased rates of amino acid substitution in the Drosophila saltans species group.
Rodríguez-Trelles F, Tarrío R, Ayala FJ. Rodríguez-Trelles F, et al. Genetics. 1999 Sep;153(1):339-50. doi: 10.1093/genetics/153.1.339. Genetics. 1999. PMID: 10471717 Free PMC article. - Tree rooting with outgroups when they differ in their nucleotide composition from the ingroup: the Drosophila saltans and willistoni groups, a case study.
Tarrío R, Rodríguez-Trelles F, Ayala FJ. Tarrío R, et al. Mol Phylogenet Evol. 2000 Sep;16(3):344-9. doi: 10.1006/mpev.2000.0813. Mol Phylogenet Evol. 2000. PMID: 10991788 - Fluctuating mutation bias and the evolution of base composition in Drosophila.
Rodríguez-Trelles F, Tarrío R, Ayala FJ. Rodríguez-Trelles F, et al. J Mol Evol. 2000 Jan;50(1):1-10. doi: 10.1007/s002399910001. J Mol Evol. 2000. PMID: 10654254 - Mutation pressure, natural selection, and the evolution of base composition in Drosophila.
Akashi H, Kliman RM, Eyre-Walker A. Akashi H, et al. Genetica. 1998;102-103(1-6):49-60. Genetica. 1998. PMID: 9720271 Review. - Chargaff's legacy.
Forsdyke DR, Mortimer JR. Forsdyke DR, et al. Gene. 2000 Dec 30;261(1):127-37. doi: 10.1016/s0378-1119(00)00472-8. Gene. 2000. PMID: 11164044 Review.
Cited by
- A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH).
Nunes WVB, Oliveira DS, Dias GR, Carvalho AB, Caruso ÍP, Biselli JM, Guegen N, Akkouche A, Burlet N, Vieira C, Carareto CMA. Nunes WVB, et al. G3 (Bethesda). 2024 Mar 6;14(3):jkad299. doi: 10.1093/g3journal/jkad299. G3 (Bethesda). 2024. PMID: 38156703 Free PMC article. - Nonrecombining genes in a recombination environment: the Drosophila "dot" chromosome.
Powell JR, Dion K, Papaceit M, Aguadé M, Vicario S, Garrick RC. Powell JR, et al. Mol Biol Evol. 2011 Jan;28(1):825-33. doi: 10.1093/molbev/msq258. Epub 2010 Oct 12. Mol Biol Evol. 2011. PMID: 20940345 Free PMC article. - Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.
Romiguier J, Ranwez V, Douzery EJ, Galtier N. Romiguier J, et al. Genome Res. 2010 Aug;20(8):1001-9. doi: 10.1101/gr.104372.109. Epub 2010 Jun 7. Genome Res. 2010. PMID: 20530252 Free PMC article. - Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila.
Singh ND, Arndt PF, Clark AG, Aquadro CF. Singh ND, et al. Mol Biol Evol. 2009 Jul;26(7):1591-605. doi: 10.1093/molbev/msp071. Epub 2009 Apr 7. Mol Biol Evol. 2009. PMID: 19351792 Free PMC article. - Variable strength of translational selection among 12 Drosophila species.
Heger A, Ponting CP. Heger A, et al. Genetics. 2007 Nov;177(3):1337-48. doi: 10.1534/genetics.107.070466. Genetics. 2007. PMID: 18039870 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous