Pancreatic tumors show high levels of hypoxia - PubMed (original) (raw)
Pancreatic tumors show high levels of hypoxia
A C Koong et al. Int J Radiat Oncol Biol Phys. 2000.
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Abstract
Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors.
Methods and materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode.
Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation.
Conclusion: Tumor hypoxia exists within pancreatic cancers.
Comment in
- Pancreatic tumors show high levels of hypoxia: regarding Koong et al. IJROBP 2000;48:919-922.
Vaupel P, Thews O, Kelleher DK. Vaupel P, et al. Int J Radiat Oncol Biol Phys. 2001 Jul 15;50(4):1099-100. doi: 10.1016/s0360-3016(01)01550-4. Int J Radiat Oncol Biol Phys. 2001. PMID: 11450680 No abstract available.
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