Regulation and functions of Rho-associated kinase - PubMed (original) (raw)
Review
. 2000 Nov 25;261(1):44-51.
doi: 10.1006/excr.2000.5046.
Affiliations
- PMID: 11082274
- DOI: 10.1006/excr.2000.5046
Review
Regulation and functions of Rho-associated kinase
M Amano et al. Exp Cell Res. 2000.
Abstract
Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase.
Copyright 2000 Academic Press.
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