X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains - PubMed (original) (raw)
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains
K F Lau et al. Mol Cell Neurosci. 2000 Nov.
Abstract
X11 alpha and X11 beta are two neuronal adaptor proteins that interact with the Alzheimer's disease amyloid precursor protein (APP). X11 alpha and X11 beta stabilise APP and inhibit production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. The mechanisms by which X11 alpha and X11 beta modulate APP processing are not clear but one possibility is that they influence the activity of the secretases that cleave APP to give rise to A beta. Presenilin-1 is required for gamma-secretase activity and here we demonstrate that both X11 alpha and X11 beta interact with presenilin-1. X11/presenilin-1 binding is via two X11 PDZ domains and sequences within the carboxy-terminus of presenilin-1. We also demonstrate that both X11 alpha and X11 beta mediate the formation of complexes between APP and presenilin-1. These results suggest that the X11 regulation of APP processing is controlled, at least in part, via their interactions with APP and presenilin-1.
Copyright 2000 Academic Press.
Similar articles
- Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N. Vingtdeux V, et al. Neurobiol Dis. 2005 Nov;20(2):625-37. doi: 10.1016/j.nbd.2005.05.004. Epub 2005 Jun 3. Neurobiol Dis. 2005. PMID: 15936948 - Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
Evin G, Zhu A, Holsinger RM, Masters CL, Li QX. Evin G, et al. J Neurosci Res. 2003 Nov 1;74(3):386-92. doi: 10.1002/jnr.10745. J Neurosci Res. 2003. PMID: 14598315 - Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808 - Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Selkoe DJ. Selkoe DJ. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. doi: 10.1073/pnas.211352598. Proc Natl Acad Sci U S A. 2001. PMID: 11572965 Free PMC article. Review. - The role of proteolysis in Alzheimer's disease.
Hooper NM, Trew AJ, Parkin ET, Turner AJ. Hooper NM, et al. Adv Exp Med Biol. 2000;477:379-90. doi: 10.1007/0-306-46826-3_39. Adv Exp Med Biol. 2000. PMID: 10849764 Review.
Cited by
- A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission.
Ho A, Morishita W, Hammer RE, Malenka RC, Sudhof TC. Ho A, et al. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1409-14. doi: 10.1073/pnas.252774899. Epub 2003 Jan 23. Proc Natl Acad Sci U S A. 2003. PMID: 12547917 Free PMC article. - X11-like protein deficiency is associated with impaired conflict resolution in mice.
Sano Y, Ornthanalai VG, Yamada K, Homma C, Suzuki H, Suzuki T, Murphy NP, Itohara S. Sano Y, et al. J Neurosci. 2009 May 6;29(18):5884-96. doi: 10.1523/JNEUROSCI.5756-08.2009. J Neurosci. 2009. PMID: 19420255 Free PMC article. - Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation.
Bartling CRO, Jensen TMT, Henry SM, Colliander AL, Sereikaite V, Wenzler M, Jain P, Maric HM, Harpsøe K, Pedersen SW, Clemmensen LS, Haugaard-Kedström LM, Gloriam DE, Ho A, Strømgaard K. Bartling CRO, et al. J Am Chem Soc. 2021 Jan 20;143(2):891-901. doi: 10.1021/jacs.0c10696. Epub 2021 Jan 5. J Am Chem Soc. 2021. PMID: 33398998 Free PMC article. - Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.
Gray EH, De Vos KJ, Dingwall C, Perkinton MS, Miller CC. Gray EH, et al. J Alzheimers Dis. 2010;21(4):1101-5. doi: 10.3233/JAD-2010-100717. J Alzheimers Dis. 2010. PMID: 20693630 Free PMC article. - Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila.
Gross GG, Feldman RM, Ganguly A, Wang J, Yu H, Guo M. Gross GG, et al. PLoS One. 2008 Jun 25;3(6):e2495. doi: 10.1371/journal.pone.0002495. PLoS One. 2008. PMID: 18575606 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases