Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats - PubMed (original) (raw)

. 2000 Nov;23(11):1395-7.

doi: 10.1248/bpb.23.1395.

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• PMID: 11085376
• DOI: 10.1248/bpb.23.1395

Free article

Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats

A Hattori et al. Biol Pharm Bull. 2000 Nov.

Free article

Abstract

An oral administration of gamma-tocotrienol (gamma-T3) or gamma-tocopherol (gamma-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (LLU-alpha, gamma-CEHC), a natriuretic compound, in plasma with a T(max) of 9 h. The configuration at C-2 of LLU-alpha produced from gamma-T3 or gamma-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-alpha was produced not only from gamma-Toc but also gamma-T3, without racemization at C-2 in rats.

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