Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells - PubMed (original) (raw)
Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells
X Qian et al. Neuron. 2000 Oct.
Free article
Abstract
Multipotent stem cells that generate both neurons and glia are widespread components of the early neuroepithelium. During CNS development, neurogenesis largely precedes gliogenesis: how is this timing achieved? Using clonal cell culture combined with long-term time-lapse video microscopy, we show that isolated stem cells from the embryonic mouse cerebral cortex exhibit a distinct order of cell-type production: neuroblasts first and glioblasts later. This is accompanied by changes in their capacity to make neurons versus glia and in their response to the mitogen EGF. Hence, multipotent stem cells alter their properties over time and undergo distinct phases of development that play a key role in scheduling production of diverse CNS cells.
Comment in
- The last shall not be first: the ordered generation of progeny from stem cells.
Morrison SJ. Morrison SJ. Neuron. 2000 Oct;28(1):1-3. doi: 10.1016/s0896-6273(00)00075-1. Neuron. 2000. PMID: 11086973 No abstract available.
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