Common genetic changes between endometriosis and ovarian cancer - PubMed (original) (raw)

Review

Common genetic changes between endometriosis and ovarian cancer

K Obata et al. Gynecol Obstet Invest. 2000.

Abstract

We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. Frequent LOH was observed on chromosome 6q (60.0%) and chromosome 10q (40.0%) in ovarian atypical endometriosis, but no PTEN mutations were observed. These findings support the hypothesis that endometrioid and clear cell ovarian carcinomas may arise through malignant transformation of endometriotic lesions.

Copyright 2000 S. Karger AG, Basel.

PubMed Disclaimer

Similar articles

• Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.
  Obata K, Morland SJ, Watson RH, Hitchcock A, Chenevix-Trench G, Thomas EJ, Campbell IG. Obata K, et al. Cancer Res. 1998 May 15;58(10):2095-7. Cancer Res. 1998. PMID: 9605750
• [An approach to early genetic alterations in precancerous cells].
  Sato N, Nishida M, Noguchi M. Sato N, et al. Hum Cell. 2000 Sep;13(3):103-8. Hum Cell. 2000. PMID: 11197771 Review. Japanese.
• [Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis].
  Castiblanco G A, Pires N Y, Wistuba O I, Riquelme S E, Andrade M L, Corvalán R A. Castiblanco G A, et al. Rev Med Chil. 2006 Mar;134(3):271-8. doi: 10.4067/s0034-98872006000300001. Epub 2006 May 2. Rev Med Chil. 2006. PMID: 16676097 Spanish.
• [Genetic analysis of endometriosis and ovarian cancer].
  Obata K, Hoshiai H. Obata K, et al. Nihon Rinsho. 2001 Jan;59 Suppl 1:217-20. Nihon Rinsho. 2001. PMID: 11235170 Review. Japanese. No abstract available.

Cited by

• Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management.
  Mandai M, Yamaguchi K, Matsumura N, Baba T, Konishi I. Mandai M, et al. Int J Clin Oncol. 2009 Oct;14(5):383-91. doi: 10.1007/s10147-009-0935-y. Epub 2009 Oct 25. Int J Clin Oncol. 2009. PMID: 19856044 Review.
• Association between atypical endometriosis and ovarian malignancies in the real world.
  So KA, Hong SR, Kim NR, Yang EJ, Shim SH, Lee SJ, Kim TJ. So KA, et al. J Ovarian Res. 2021 Aug 28;14(1):110. doi: 10.1186/s13048-021-00865-2. J Ovarian Res. 2021. PMID: 34454550 Free PMC article.
• Novel Therapeutic Strategies for Refractory Ovarian Cancers: Clear Cell and Mucinous Carcinomas.
  Shoji T, Tatsuki S, Abe M, Tomabechi H, Takatori E, Kaido Y, Nagasawa T, Kagabu M, Baba T, Itamochi H. Shoji T, et al. Cancers (Basel). 2021 Dec 4;13(23):6120. doi: 10.3390/cancers13236120. Cancers (Basel). 2021. PMID: 34885229 Free PMC article. Review.
• Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects.
  Wei JJ, William J, Bulun S. Wei JJ, et al. Int J Gynecol Pathol. 2011 Nov;30(6):553-68. doi: 10.1097/PGP.0b013e31821f4b85. Int J Gynecol Pathol. 2011. PMID: 21979592 Free PMC article. Review.
• Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review.
  Mikhaleva LM, Davydov AI, Patsap OI, Mikhaylenko EV, Nikolenko VN, Neganova ME, Klochkov SG, Somasundaram SG, Kirkland CE, Aliev G. Mikhaleva LM, et al. Adv Ther. 2020 Jun;37(6):2580-2603. doi: 10.1007/s12325-020-01363-5. Epub 2020 May 8. Adv Ther. 2020. PMID: 32385745 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • S. Karger AG, Basel, Switzerland

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program