A network of protein-protein interactions in yeast - PubMed (original) (raw)
. 2000 Dec;18(12):1257-61.
doi: 10.1038/82360.
Affiliations
- PMID: 11101803
- DOI: 10.1038/82360
A network of protein-protein interactions in yeast
B Schwikowski et al. Nat Biotechnol. 2000 Dec.
Abstract
A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63% of the interactions occurring between proteins with a common functional assignment and 76% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.
Comment in
- Protein networks-built by association.
Mayer ML, Hieter P. Mayer ML, et al. Nat Biotechnol. 2000 Dec;18(12):1242-3. doi: 10.1038/82342. Nat Biotechnol. 2000. PMID: 11101798 No abstract available.
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