Target selection for structural genomics - PubMed (original) (raw)
Review
. 2000 Nov:7 Suppl:967-9.
doi: 10.1038/80747.
Affiliations
- PMID: 11104002
- DOI: 10.1038/80747
Review
Target selection for structural genomics
S E Brenner. Nat Struct Biol. 2000 Nov.
Abstract
Structural genomics aims to use high-throughput structure determination and computational analysis to provide three-dimensional models of every tractable protein. The process of choosing proteins for experimental structure characterization is known as target selection. In this nomenclature, the targets are regions of proteins to be studied by crystallography or NMR. Selection of the targets is principally a computational process of restricting candidate proteins to those that are tractable and of unknown structure, and prioritizing according to expected interest and accessibility.
Similar articles
- A tour of structural genomics.
Brenner SE. Brenner SE. Nat Rev Genet. 2001 Oct;2(10):801-9. doi: 10.1038/35093574. Nat Rev Genet. 2001. PMID: 11584296 Review. - Structural genomics projects in Japan.
Yokoyama S, Hirota H, Kigawa T, Yabuki T, Shirouzu M, Terada T, Ito Y, Matsuo Y, Kuroda Y, Nishimura Y, Kyogoku Y, Miki K, Masui R, Kuramitsu S. Yokoyama S, et al. Nat Struct Biol. 2000 Nov;7 Suppl:943-5. doi: 10.1038/80712. Nat Struct Biol. 2000. PMID: 11103994 - An overview of structural genomics.
Burley SK. Burley SK. Nat Struct Biol. 2000 Nov;7 Suppl:932-4. doi: 10.1038/80697. Nat Struct Biol. 2000. PMID: 11103991 - Structural genomics in the biotechnology sector.
Dry S, McCarthy S, Harris T. Dry S, et al. Nat Struct Biol. 2000 Nov;7 Suppl:946-9. doi: 10.1038/80718. Nat Struct Biol. 2000. PMID: 11103995 - Protein NMR spectroscopy in structural genomics.
Montelione GT, Zheng D, Huang YJ, Gunsalus KC, Szyperski T. Montelione GT, et al. Nat Struct Biol. 2000 Nov;7 Suppl:982-5. doi: 10.1038/80768. Nat Struct Biol. 2000. PMID: 11104006 Review.
Cited by
- Comparative genomics of Archaea: how much have we learned in six years, and what's next?
Makarova KS, Koonin EV. Makarova KS, et al. Genome Biol. 2003;4(8):115. doi: 10.1186/gb-2003-4-8-115. Epub 2003 Jul 16. Genome Biol. 2003. PMID: 12914651 Free PMC article. Review. - Structural genomics: a pipeline for providing structures for the biologist.
Chance MR, Bresnick AR, Burley SK, Jiang JS, Lima CD, Sali A, Almo SC, Bonanno JB, Buglino JA, Boulton S, Chen H, Eswar N, He G, Huang R, Ilyin V, McMahan L, Pieper U, Ray S, Vidal M, Wang LK. Chance MR, et al. Protein Sci. 2002 Apr;11(4):723-38. doi: 10.1110/ps.4570102. Protein Sci. 2002. PMID: 11910018 Free PMC article. Review. No abstract available. - H-DROP: an SVM based helical domain linker predictor trained with features optimized by combining random forest and stepwise selection.
Ebina T, Suzuki R, Tsuji R, Kuroda Y. Ebina T, et al. J Comput Aided Mol Des. 2014 Aug;28(8):831-9. doi: 10.1007/s10822-014-9763-x. Epub 2014 Jun 26. J Comput Aided Mol Des. 2014. PMID: 24965847 - sgTarget: a target selection resource for structural genomics.
Rodrigues AP, Grant BJ, Hubbard RE. Rodrigues AP, et al. Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W225-30. doi: 10.1093/nar/gkl121. Nucleic Acids Res. 2006. PMID: 16844998 Free PMC article. - Coverage of whole proteome by structural genomics observed through protein homology modeling database.
Yura K, Yamaguchi A, Go M. Yura K, et al. J Struct Funct Genomics. 2006 Jun;7(2):65-76. doi: 10.1007/s10969-006-9010-3. Epub 2006 Dec 5. J Struct Funct Genomics. 2006. PMID: 17146617 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources