Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast - PubMed (original) (raw)
Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast
T Chen et al. Science. 2000.
Abstract
Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.
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